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LDAH Knockout Cell Lines

Gene: LDAH

Official Full Name: lipid droplet associated hydrolaseprovided by HGNC

Gene Summary: Predicted to enable sterol ester esterase activity. Involved in cholesterol homeostasis and intracellular triglyceride homeostasis. Acts upstream of with a positive effect on lipid droplet fusion. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16579 LDAH Knockout cell line (HeLa) Human LDAH 1:3~1:6 Negative Online Inquiry
KO16580 LDAH Knockout cell line (HCT 116) Human LDAH 1:2~1:4 Negative Online Inquiry
KO16581 LDAH Knockout cell line (HEK293) Human LDAH 1:3~1:6 Negative Online Inquiry
KO16582 LDAH Knockout cell line (A549) Human LDAH 1:3~1:4 Negative Online Inquiry

Background

LDAH Gene Knockout Cell Lines are highly specialized cell models characterized by the targeted disruption of the LDAH (Long-Chain Dicarboxylic Acid Hydrolase) gene. These cell lines are utilized to investigate the biological roles and regulatory mechanisms associated with LDAH, which is implicated in lipid metabolism and various metabolic disorders. By employing advanced CRISPR-Cas9 gene editing technology, researchers can produce LDAH knockout cells that enable precise analysis of gene function and its downstream physiological effects.

The primary function of LDAH Gene Knockout Cell Lines lies in their ability to elucidate the contribution of LDAH to metabolic pathways and its potential involvement in disease states, such as obesity, diabetes, and cardiovascular disorders. The absence of the LDAH protein in these cell lines offers a unique platform to assess how alterations in lipid profiles and fatty acid metabolism can influence cellular behaviors, such as proliferation, apoptosis, and inflammation.

Scientifically, the availability of LDAH knockout models is crucial for biomedical research as they serve as valuable tools for drug discovery, biomarker identification, and the development of therapeutic strategies targeting metabolic diseases. Their applications extend to academic and pharmaceutical research settings, where understanding the physiological implications of LDAH deficiency can guide innovative treatment approaches.

Compared to conventional cell models that may not accurately represent LDAH functionality, LDAH Gene Knockout Cell Lines provide a distinct advantage through their specificity and reliability. Unlike alternatives, these knockout models facilitate high-throughput screening and enable researchers to profile the metabolic effects of compounds with an unprecedented level of detail.

For researchers and clinicians focused on metabolic research and therapeutic development, investing in LDAH Gene Knockout Cell Lines represents an opportunity to harness cutting-edge science to advance their studies and enhance clinical outcomes. Our expertise in developing robust biological models ensures the highest quality and reproducibility, making us a trusted partner in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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