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LCLAT1 Knockout Cell Lines

Gene: LCLAT1

Official Full Name: lysocardiolipin acyltransferase 1provided by HGNC

Gene Summary: Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21231 LCLAT1 Knockout cell line (HeLa) Human LCLAT1 1:3~1:6 Negative Online Inquiry
KO21232 LCLAT1 Knockout cell line (HCT 116) Human LCLAT1 1:2~1:4 Negative Online Inquiry
KO21233 LCLAT1 Knockout cell line (HEK293) Human LCLAT1 1:3~1:6 Negative Online Inquiry
KO21234 LCLAT1 Knockout cell line (A549) Human LCLAT1 1:3~1:4 Negative Online Inquiry

Background

LCLAT1 Gene Knockout Cell Lines are specially engineered cell lines in which the LCLAT1 gene has been disrupted, enabling researchers to investigate the functional role of this gene in various biological processes. The LCLAT1 gene encodes a protein that is crucial for lipid metabolism, specifically in the metabolism of long-chain acyl-CoA species. By utilizing CRISPR/Cas9 technology or similar gene-editing techniques, these cell lines provide a powerful tool for studying the consequences of LCLAT1 knockout on cellular physiology, including alterations in lipid profile, energy homeostasis, and cell signaling pathways.

The mechanism of action underlying the utility of LCLAT1 knockout cell lines lies in their ability to mimic specific physiological or pathological conditions, allowing scientists to explore the implications of LCLAT1 loss in relevant cellular contexts. This can shed light on how dysregulation of lipid metabolism is linked to various diseases, including obesity, diabetes, and cardiovascular disorders. These cell lines serve as models for drug screening and therapeutic development, facilitating the identification of novel intervention strategies targeting dysregulated lipid metabolism.

The scientific importance of LCLAT1 Gene Knockout Cell Lines is underscored by their extensive applicability in both basic research and clinical studies. Researchers can leverage these tools to validate hypotheses about the role of LCLAT1 in disease mechanisms, dissect metabolic pathways, and evaluate the therapeutic potential of modulators that target lipid metabolism.

What sets the LCLAT1 Gene Knockout Cell Lines apart from alternative models is their precise genetic modification, allowing for high specificity and reproducibility in experimental outcomes. Unlike traditional cell culture models that may present confounding variables, the knockout of LCLAT1 ensures that observed effects can be directly attributed to the absence of this key gene.

For researchers and clinicians focused on metabolic research and therapeutic advancements, the LCLAT1 Gene Knockout Cell Lines represent an invaluable asset. They offer a robust platform for insightful exploration of lipid metabolism and its implications in disease, potentially leading to breakthroughs in understanding and managing metabolic disorders.

With a commitment to delivering high-quality and scientifically robust biological tools, our company specializes in the development of innovative products like the LCLAT1 Gene Knockout Cell Lines, ensuring that researchers are equipped with the means to push the boundaries of biomedical discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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