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LAMA5 Knockout Cell Lines

Gene: LAMA5

Official Full Name: laminin subunit alpha 5provided by HGNC

Gene Summary: This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10262 LAMA5 Knockout cell line (HeLa) Human LAMA5 1:3~1:6 Negative Online Inquiry
KO10263 LAMA5 Knockout cell line (HCT 116) Human LAMA5 1:2~1:4 Negative Online Inquiry
KO10264 LAMA5 Knockout cell line (HEK293) Human LAMA5 1:3~1:6 Negative Online Inquiry
KO10265 LAMA5 Knockout cell line (A549) Human LAMA5 1:3~1:4 Negative Online Inquiry

Background

LAMA5 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the LAMA5 gene, which encodes the lambda-5 chain of laminin, a key component of the extracellular matrix. These knockout cell lines are generated through precise gene-editing techniques, such as CRISPR-Cas9, resulting in a loss of function of the LAMA5 gene. This innovative tool provides researchers with a unique platform to explore the critical roles that LAMA5 plays in cellular processes, including cell adhesion, migration, and tissue organization.

The primary function of these cell lines is to enable the investigation of the physiological and pathological implications of LAMA5 deficiency. By studying the cellular behaviors and phenotypic alterations arising from the absence of this gene, scientists can gain insights into various biological processes and disease states, particularly in the fields of cancer research, developmental biology, and regenerative medicine. The mechanistic understanding derived from these studies can illuminate the role of laminins in cell signaling and the extracellular matrix's influence on cell fate and behavior.

The scientific importance of LAMA5 Gene Knockout Cell Lines extends to their versatile applications in both research and clinical settings. These models can be utilized for drug screening, biomarker discovery, and the elucidation of molecular pathways that contribute to disease onset and progression. Furthermore, they serve as a valuable resource for academic and pharmaceutical researchers aiming to develop targeted therapies that modulate pathways influenced by LAMA5.

Compared to traditional cell lines, LAMA5 Gene Knockout Cell Lines offer unique advantages including enhanced specificity in studying LAMA5 functions, reduced off-target effects common in less precise methods, and the ability to achieve reproducible results across experiments. These attributes make them an indispensable resource for researchers aiming for accuracy and reliability in their investigations.

In summary, LAMA5 Gene Knockout Cell Lines are an essential asset for advancing our understanding of cellular mechanisms and the pathological roles of laminins. Our company specializes in the development of cutting-edge biological products that empower researchers and clinicians in their quest for scientific breakthroughs. Our commitment to quality and innovation ensures that our products meet the highest standards, providing reliable tools for the progression of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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