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LACTB Knockout Cell Lines

Gene: LACTB

Official Full Name: lactamase betaprovided by HGNC

Gene Summary: This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00203 LACTB Knockout cell line (HEK293) Human LACTB 1:3~1:6 Negative Online Inquiry
KO30800 LACTB Knockout cell line (HeLa) Human LACTB 1:3~1:6 Negative Online Inquiry
KO30801 LACTB Knockout cell line (HCT 116) Human LACTB 1:2~1:4 Negative Online Inquiry
KO30802 LACTB Knockout cell line (A549) Human LACTB 1:3~1:4 Negative Online Inquiry

Background

LACTB Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to enable the study of the lactate dehydrogenase B (LACTB) gene, known for its critical role in cellular metabolism and tumor suppression. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide researchers with a tool to investigate the downstream effects of LACTB gene deficiency and its implications in various biological processes, such as metabolic pathways, apoptosis, and the tumor microenvironment.

The primary function of LACTB is to encode a mitochondrial enzyme involved in the conversion of lactate to pyruvate, thereby influencing energy production and metabolic homeostasis. By offering a model where the LACTB gene is silenced, these cell lines facilitate the exploration of how its absence alters cellular metabolism, gene expression profiles, and overall cell proliferation. This detailed mechanistic insight is invaluable for understanding disease mechanisms, especially in cancer research, where metabolic dysregulation is a hallmark.

In terms of scientific importance, LACTB Gene Knockout Cell Lines hold immense potential for both fundamental and translational research. They allow for the identification of novel therapeutic targets, assessment of drug efficacy, and the study of metabolic reprogramming in various diseases. Researchers and clinicians can employ these models to conduct high-throughput screening or in-depth metabolic analyses, thereby accelerating the discovery of innovative treatment strategies.

Furthermore, compared to traditional methods of gene knockout, our LACTB Gene Knockout Cell Lines offer a streamlined and efficient solution with reduced off-target effects and improved reproducibility. The precise genetic modification ensures that the outcomes of experiments are both reliable and informative, making these cell lines a superior choice for researchers aiming to engage in high-quality, impactful work.

For researchers and clinicians keen on advancing their understanding of metabolic pathways and cancer biology, LACTB Gene Knockout Cell Lines provide unmatched value, yielding insights that can lead to breakthrough therapeutic developments. Our company leverages extensive expertise in genetic engineering and cell line development, ensuring that our products meet the highest standards of quality and reliability, thereby enhancing your research capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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