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L3MBTL3 Knockout Cell Lines

Gene: L3MBTL3

Official Full Name: L3MBTL histone methyl-lysine binding protein 3provided by HGNC

Gene Summary: This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and are associated with the repression of gene expression. The encoded protein may regulate hematopoiesis. Homozygous deletion of this gene has been observed in human patients with medulloblastoma. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09447 L3MBTL3 Knockout cell line (HeLa) Human L3MBTL3 1:3~1:6 Negative Online Inquiry
KO09448 L3MBTL3 Knockout cell line (HCT 116) Human L3MBTL3 1:2~1:4 Negative Online Inquiry
KO09449 L3MBTL3 Knockout cell line (HEK293) Human L3MBTL3 1:3~1:6 Negative Online Inquiry
KO09450 L3MBTL3 Knockout cell line (A549) Human L3MBTL3 1:3~1:4 Negative Online Inquiry

Background

L3MBTL3 Gene Knockout Cell Lines refer to genetically modified cell lines in which the L3MBTL3 gene has been specifically disrupted, creating a valuable tool for the study of gene function and regulation. This product allows researchers to investigate the biological roles of L3MBTL3, which is implicated in several critical processes, such as chromatin regulation, cellular differentiation, and cancer development. By using CRISPR-Cas9 or other gene-editing technologies to generate these knockout lines, scientists can effectively analyze the consequences of L3MBTL3 loss on cellular pathways and phenotypes.

The primary function of L3MBTL3 is to regulate gene expression through its involvement in chromatin remodeling and the maintenance of transcriptional fidelity. The knockout of this gene enables the exploration of its role in cellular mechanisms such as gene silencing and epigenetic modifications, critical in both normal development and oncogenesis. Researchers in molecular biology and cancer genetics may find these cellular models particularly beneficial for identifying therapeutic targets and potential biomarkers for disease progression.

Compared to traditional methods like RNA interference or chemical inhibitors, L3MBTL3 Gene Knockout Cell Lines offer a more precise genetic approach that can provide clearer insights into the gene's functional contributions. This specificity can lead to more reproducible and interpretable results, which is invaluable in both research and clinical applications, especially in drug development and personalized medicine.

For academic and industrial researchers seeking to enhance their understanding of gene interactions or the mechanistic underpinnings of disease, these knockout cell lines represent an innovative and essential resource. The ability to precisely dissect pathways involving L3MBTL3 can accelerate advancements in therapeutic strategies.

With extensive expertise in genetic engineering and a robust portfolio of biological products, our company is committed to providing high-quality, customizable solutions tailored to meet the dynamic needs of the scientific community. Our L3MBTL3 Gene Knockout Cell Lines are a testament to our dedication to advancing research and fostering innovation in biological sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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