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KMT2B Knockout Cell Lines

Gene: KMT2B

Official Full Name: lysine methyltransferase 2Bprovided by HGNC

Gene Summary: This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04932 KMT2B Knockout cell line (HeLa) Human KMT2B 1:3~1:6 Negative Online Inquiry
KO04933 KMT2B Knockout cell line (HCT 116) Human KMT2B 1:2~1:4 Negative Online Inquiry
KO04934 KMT2B Knockout cell line (HEK293) Human KMT2B 1:3~1:6 Negative Online Inquiry
KO04935 KMT2B Knockout cell line (A549) Human KMT2B 1:3~1:4 Negative Online Inquiry

Background

KMT2B Gene Knockout Cell Lines represent a specialized biological tool designed to investigate the function and role of the KMT2B gene within cellular contexts. Utilizing state-of-the-art CRISPR/Cas9 gene-editing technology, these cell lines have been genetically modified to completely disrupt the expression of the KMT2B gene, a known regulator of histone methylation involved in epigenetic gene regulation. By eliminating KMT2B activity, researchers can examine subsequent alterations in gene expression, cellular behavior, and phenotypic outcomes, creating valuable insights into various biological processes and diseases.

The primary mechanism of action involves targeted gene disruption that leads to the absence of KMT2B protein, thereby allowing researchers to assess the gene's influence on oncogenic pathways, neurodevelopmental processes, and other critical functions. The significance of KMT2B is underscored by its association with disorders such as Schizophrenia and its potential role in tumorigenesis. Consequently, the KMT2B Gene Knockout Cell Lines serve as a crucial platform for academic and industry research, providing opportunities for drug discovery and therapeutic interventions.

What sets our KMT2B Gene Knockout Cell Lines apart from similar products is their optimized protocols for precise knockout efficiency and the rigorous validation of gene editing integrity. Unlike conventional approaches, our cell lines come pre-validated for genomic integrity, ensuring reliability in experimental outcomes. These advanced characteristics enable researchers to save time and resources, enhancing their ability to generate reproducible and meaningful results.

The value of KMT2B Gene Knockout Cell Lines is particularly evident to researchers and clinicians focused on the genetic underpinnings of diseases. They offer a streamlined approach to exploring gene function and developing potential treatments, ultimately accelerating the pace of discovery in fields such as oncology and neurobiology. Our company has a longstanding commitment to providing high-quality biological products, with a robust support system for users to maximize their research potential and applications.

Please note that all services are for research use only. Not intended for any clinical use.

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