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KLK4 Knockout Cell Lines

Gene: KLK4

Official Full Name: kallikrein related peptidase 4provided by HGNC

Gene Summary: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33029 KLK4 Knockout cell line (HEK293) Human KLK4 1:3~1:6 Negative Online Inquiry

Background

KLK4 Gene Knockout Cell Lines are advanced biological tools specifically engineered to facilitate research in the understanding of the kallikrein-related peptidase 4 (KLK4) gene, which is implicated in various physiological and pathological processes, including cancer progression and tissue remodeling. These cell lines serve as a basis for in-depth studies into the functional roles of KLK4, allowing researchers to analyze the gene's contributions to disease pathology, development, and potential therapeutic strategies.

These knockout cell lines operate by utilizing CRISPR-Cas9 gene-editing technology to precisely remove or disrupt the expression of the KLK4 gene. This method creates a cellular environment in which the absence of KLK4 results in observable phenotypic changes and altered signaling pathways, revealing insights into the gene's functional roles. Researchers can utilize these knockout lines to study KLK4's involvement in tumor microenvironments, metastasis, and its potential as a biomarker for certain cancers.

The scientific importance of KLK4 Gene Knockout Cell Lines extends to both basic and translational research, making them invaluable in the quest for novel cancer therapies. By elucidating the cancer-related roles of KLK4, these cell lines contribute to a better understanding of tumor biology and may aid in the identification of new therapeutic targets.

Unlike other genetic models, KLK4 knockout cell lines offer specificity and reliability through the use of established methodologies. Their generation is backed by rigorous validation processes, ensuring higher confidence in replicating results across different research studies. Additionally, they can be easily modified and maintained, making them an accessible resource for laboratories regardless of their scale.

For researchers and clinicians aiming to dissect the multifaceted roles of KLK4 in health and disease, these knockout cell lines provide a powerful and essential tool. Their development stems from our commitment to advancing scientific knowledge through reliable and cutting-edge biological products. At our company, we pride ourselves on offering high-quality, innovative solutions tailored to meet the diverse needs of the biomedical research community.

Please note that all services are for research use only. Not intended for any clinical use.

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