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KLHL20 Knockout Cell Lines

Gene: KLHL20

Official Full Name: kelch like family member 20provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01021 KLHL20 Knockout cell line (HEK293) Human KLHL20 1:3~1:6 Negative Online Inquiry
KO27713 KLHL20 Knockout cell line (HeLa) Human KLHL20 1:3~1:6 Negative Online Inquiry
KO27714 KLHL20 Knockout cell line (HCT 116) Human KLHL20 1:2~1:4 Negative Online Inquiry
KO27715 KLHL20 Knockout cell line (A549) Human KLHL20 1:3~1:4 Negative Online Inquiry

Background

KLHL20 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the functional implications of KLHL20 gene loss in various biological contexts. The KLHL20 gene encodes a protein that belongs to the kelch-like family of proteins, which play crucial roles in cellular processes such as protein ubiquitination, signaling, and cytoskeletal organization. By utilizing CRISPR-Cas9 technology, these knockout cell lines exhibit a precise and permanent deletion of the KLHL20 gene, allowing researchers to investigate the resultant phenotypic changes and the underlying molecular pathways associated with KLHL20 suppression.

The primary mechanism of action lies in the targeted disruption of the KLHL20 gene, resulting in the absence of its encoded protein. This facilitates in-depth studies into physiological and pathological roles of KLHL20, contributing to a better understanding of diseases where this protein is implicated, including certain cancers and neurodegenerative disorders. In research and clinical settings, KLHL20 knockout cell lines are invaluable for drug discovery, biomarker identification, and basic research inquiries into gene function.

The distinct advantages of KLHL20 Gene Knockout Cell Lines include their robust design, reproducibility, and the ability to offer a controlled environment for investigating gene function without the confounding effects of a wild-type background. Compared to alternative models like transient knockdowns or non-customized knockout lines, these stable cell lines allow for prolonged experiments and more consistent results.

For researchers and clinicians focused on unraveling the complexities of gene function and its impact on human health, KLHL20 Gene Knockout Cell Lines offer a unique tool that enhances experimental accuracy and provides deeper insights into genetic mechanisms. With years of experience in the development of cutting-edge biological models, our company is committed to delivering high-quality products that empower scientific discovery and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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