Gene: KL
Official Full Name: klothoprovided by HGNC
Gene Summary: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00385 | KL Knockout cell line(Hep G2) | Human | KL | 1:2~1:4 | Negative | Online Inquiry |
KL Gene Knockout Cell Lines are advanced biological models specifically designed for studying gene function and the molecular mechanisms underlying various biological processes. These cell lines are generated using CRISPR-Cas9 technology, a precise genome editing tool that allows for the targeted disruption of specific genes, resulting in a knockout phenotype. By removing or altering gene expression, researchers can directly observe the resultant biological variations, enabling them to dissect the roles of specific genes in cellular functions, disease processes, and therapeutic responses.
The primary functions of KL Gene Knockout Cell Lines lie in their ability to facilitate functional genomics studies, drug discovery, and personalized medicine approaches. By enabling researchers to examine gene interactions and pathways, these cell lines serve as pivotal tools for identifying potential therapeutic targets and biomarkers. Their robust design ensures consistent and reproducible genetic modifications, allowing for high-throughput screening and validation of candidate compounds in a variety of disease models, including cancer, metabolic disorders, and neurodegenerative diseases.
From a scientific perspective, the value of KL Gene Knockout Cell Lines is amplified by their adaptability to various research settings. These models are particularly advantageous due to their accessibility and the specificity of gene disruptions, which often provide clearer biological insights compared to traditional models. Unlike alternative systems, such as siRNA or shRNA knockdowns that produce transient effects, KL Gene Knockout Cell Lines offer permanent, stable gene disruption, allowing long-term studies to uncover slow-evolving or complex phenotypic changes.
For researchers and clinicians, the implications are profound. The ability to manipulate genes with such precision not only accelerates the pace of scientific discovery but also enhances the potential for developing innovative treatment strategies and advancing therapeutic research. By using KL Gene Knockout Cell Lines, users can propel their understanding of gene functionality and its relevance to human health and disease.
Our company has extensive expertise in gene editing technologies, dedicating itself to providing high-quality biological products that empower researchers in their quest for discovery. We are committed to supporting the scientific community with cutting-edge tools that enhance research outcomes and drive breakthroughs in molecular biology and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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