Home / KIRREL1 Knockout Cell Lines

KIRREL1 Knockout Cell Lines

Gene: KIRREL1

Official Full Name: kirre like nephrin family adhesion molecule 1provided by HGNC

Gene Summary: NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16702 KIRREL1 Knockout cell line (HeLa) Human KIRREL1 1:3~1:6 Negative Online Inquiry
KO16703 KIRREL1 Knockout cell line (HCT 116) Human KIRREL1 1:2~1:4 Negative Online Inquiry
KO16704 KIRREL1 Knockout cell line (HEK293) Human KIRREL1 1:3~1:6 Negative Online Inquiry
KO16705 KIRREL1 Knockout cell line (A549) Human KIRREL1 1:3~1:4 Negative Online Inquiry

Background

KIRREL1 Gene Knockout Cell Lines are specialized cellular systems developed for research on the KIRREL1 gene, which plays a critical role in neuronal development and synaptic functions. These cell lines have been engineered using CRISPR-Cas9 technology to induce targeted mutations in the KIRREL1 gene, allowing for the study of its physiological roles and associated disease mechanisms.

The primary function of KIRREL1 is to regulate cell adhesion and neuronal connectivity, impacting synapse formation and maintenance. By utilizing these knockout cell lines, researchers can observe the cellular and molecular changes that occur in the absence of KIRREL1, allowing for an in-depth understanding of its contributions to neural development and potential links to neurological disorders such as autism spectrum disorders and schizophrenia.

The scientific importance of KIRREL1 Gene Knockout Cell Lines extends to both basic research and clinical applications. These cell lines provide invaluable insights into the signaling pathways involved in neuronal integrity, making them essential tools for drug discovery and the development of therapeutic strategies targeting synaptic dysfunction. Their use can expedite the identification of biomarkers and potential treatment targets for a variety of neurodevelopmental diseases.

What sets our KIRREL1 Gene Knockout Cell Lines apart from available alternatives is their high specificity and reproducibility, ensuring consistent results across experiments. Our rigorous validation processes confirm the efficiency of gene knockout, and comprehensive characterization of these cell lines guarantees their suitability for various experimental applications.

For researchers and clinicians focusing on neurobiology and related fields, these cell lines offer a unique value, enabling the exploration of KIRREL1's multifaceted roles in a controlled environment. Additionally, leveraging our expertise in cellular engineering and genetic manipulation, we provide comprehensive support, including optimization protocols and consultations, to ensure that our customers achieve their research goals effectively.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.