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KIR2DL5A Knockout Cell Lines

Gene: KIR2DL5A

Official Full Name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5Aprovided by HGNC

Gene Summary: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16710 KIR2DL5A Knockout cell line (HeLa) Human KIR2DL5A 1:3~1:6 Negative Online Inquiry
KO16711 KIR2DL5A Knockout cell line (HCT 116) Human KIR2DL5A 1:2~1:4 Negative Online Inquiry
KO16712 KIR2DL5A Knockout cell line (HEK293) Human KIR2DL5A 1:3~1:6 Negative Online Inquiry
KO16713 KIR2DL5A Knockout cell line (A549) Human KIR2DL5A 1:3~1:4 Negative Online Inquiry

Background

KIR2DL5A Gene Knockout Cell Lines are genetically modified human cell lines that have had the KIR2DL5A gene inactivated through advanced CRISPR-Cas9 technology. KIR2DL5A is a member of the killer immunoglobulin-like receptor (KIR) family, which plays a crucial role in regulating immune responses and NK cell activity. The knockout of this gene allows researchers to investigate the specific contributions of KIR2DL5A to immune system modulation and its role in various pathologies, including infections and cancer.

These cell lines function as invaluable tools for studying the mechanisms through which KIR2DL5A influences natural killer cell function, cytokine production, and immune evasion strategies employed by tumors. By utilizing these knockout models, researchers can elucidate the pathways activated during immune responses and gain insights into therapeutic targets for improving anti-tumor immunity or enhancing vaccine efficacy.

The scientific importance of KIR2DL5A Gene Knockout Cell Lines extends to both basic research and clinical applications. They can be employed in drug discovery, specifically in testing compounds that may restore or enhance immune function. Additionally, they are instrumental in the development of immunotherapies aimed at cancer treatment, providing a platform for evaluating the efficacy of potential interventions.

One unique selling point of these knockout cell lines is the precision afforded by CRISPR-Cas9 gene editing, which offers a clean knockout without off-target effects that can confound experimental results. Compared to traditional methods of gene silencing or knockout, which often suffer from incomplete or non-specific targeting, KIR2DL5A Gene Knockout Cell Lines provide unparalleled consistency and reliability in experimental design.

For researchers and clinicians focused on understanding the complexities of immune modulation and its implications for health and disease, these cell lines represent a crucial asset in translating basic immunological research into clinical advancements. Our commitment to quality and innovation is reflected in our state-of-the-art genetic engineering capabilities, ensuring that we offer not only products but also solutions that drive progress in the field of immunology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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