Gene: KIF14
Official Full Name: kinesin family member 14provided by HGNC
Gene Summary: This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32488 | KIF14 Knockout cell line (HeLa) | Human | KIF14 | 1:3~1:6 | Negative | Online Inquiry |
KO32489 | KIF14 Knockout cell line (HCT 116) | Human | KIF14 | 1:2~1:4 | Negative | Online Inquiry |
KO32490 | KIF14 Knockout cell line (HEK293) | Human | KIF14 | 1:3~1:6 | Negative | Online Inquiry |
KO32491 | KIF14 Knockout cell line (A549) | Human | KIF14 | 1:3~1:4 | Negative | Online Inquiry |
KIF14 Gene Knockout Cell Lines are innovative biological tools designed to facilitate the study of KIF14, a key gene implicated in various cellular processes, including cell division and chromosome segregation during mitosis. This product is created through precise genetic engineering techniques, enabling researchers to produce cell lines that lack the functional KIF14 gene. By establishing a model that highlights the absence of this specific gene, scientists can effectively investigate its role in developmental biology, cancer progression, and potential therapeutic targets.
The primary function of these knockout cell lines is to elucidate the mechanisms by which KIF14 influences cell cycle dynamics. Without the expression of KIF14, researchers can observe alterations in cellular behavior, such as defects in cytokinesis or chromosomal stability, thereby allowing for deeper insights into its functional pathways. These observations are crucial in understanding the molecular underpinnings of diseases, including various cancers where KIF14 is often dysregulated.
The scientific importance of KIF14 Gene Knockout Cell Lines is evident in both research and clinical applications. They offer a valuable platform for drug discovery, allowing for the screening of therapeutic compounds that may restore normal cellular functions or induce apoptosis in cancerous cells. Furthermore, these cell lines can serve as a model for genetic studies, facilitating the examination of gene interactions and signaling pathways.
What sets KIF14 Gene Knockout Cell Lines apart from alternative products is their reliability and the ease of use in experimental setups, which are optimized for reproducibility. Unlike traditional methods of gene silencing, these knockout models provide a definitive and stable genetic background for straightforward interpretation of results. Additionally, they are rigorously validated, ensuring that scientists work with high-quality, consistent cell lines.
For researchers and clinicians, the value of KIF14 Gene Knockout Cell Lines lies in their capacity to drive innovative discoveries in gene function and therapy. This product is essential for those striving to understand the complexities of cellular mechanisms and their implications in health and disease. With a commitment to advancing scientific inquiry, our company prides itself on delivering high-quality biological products backed by extensive expertise and tailored support for users in the academic and biopharmaceutical sectors.
Please note that all services are for research use only. Not intended for any clinical use.
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