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KIAA1549 Knockout Cell Lines

Gene: KIAA1549

Official Full Name: KIAA1549provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16760 KIAA1549 Knockout cell line (HeLa) Human KIAA1549 1:3~1:6 Negative Online Inquiry
KO16761 KIAA1549 Knockout cell line (HCT 116) Human KIAA1549 1:2~1:4 Negative Online Inquiry
KO16762 KIAA1549 Knockout cell line (HEK293) Human KIAA1549 1:3~1:6 Negative Online Inquiry
KO16763 KIAA1549 Knockout cell line (A549) Human KIAA1549 1:3~1:4 Negative Online Inquiry

Background

KIAA1549 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the expression of the KIAA1549 gene, which is often implicated in various oncogenic processes, particularly in gliomas. By utilizing CRISPR-Cas9 or other targeted gene-editing techniques, these cell lines allow researchers to investigate the specific roles that KIAA1549 plays in cellular functions, signaling pathways, and tumorigenesis.

The primary mechanism of action involves the introduction of double-strand breaks in the KIAA1549 gene locus, leading to mutations that result in the loss of function of this crucial gene. This gene knockout model facilitates a deeper understanding of the KIAA1549-mediated pathways and how its dysregulation contributes to cancer. In addition to studying its role in tumor biology, these cell lines can be instrumental in drug discovery, allowing for the identification of therapeutic targets and the evaluation of compounds that could inhibit cancer growth.

Scientifically, KIAA1549 Gene Knockout Cell Lines are invaluable for advancing research in oncology and genetics. Their applications extend into preclinical studies, enabling clinicians and researchers to explore the efficacy of novel treatments in a controlled environment. Compared to other available models, these knockout cell lines offer precise gene targeting, high reproducibility, and the ability to mimic the tumor microenvironment more closely, enhancing translational research efforts.

The specific advantages of utilizing KIAA1549 Gene Knockout Cell Lines include their ability to provide clear insights into gene function, facilitate the development of personalized medicine strategies, and reduce the time required to obtain meaningful experimental data in comparison to traditional methods. By leveraging these advanced cellular models, researchers can accelerate their discoveries, providing a competitive edge in the fast-evolving field of cancer research.

At our company, we pride ourselves on our extensive expertise in creating innovative genetic models that empower scientists to unravel complex biological systems. Our commitment to quality and precision in developing KIAA1549 Gene Knockout Cell Lines underscores our dedication to supporting the research community in their quest for understanding and treatment of cancer.

Please note that all services are for research use only. Not intended for any clinical use.

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