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KIAA0753 Knockout Cell Lines

Gene: KIAA0753

Official Full Name: KIAA0753provided by HGNC

Gene Summary: This gene encodes a subunit of a protein complex that regulates ciliogenesis and cilia maintenance. The encoded protein has also been shown to regulate centriolar duplication. Mutations in this gene cause an orofaciodigital syndrome and a form of Joubert syndrome in human patients. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32654 KIAA0753 Knockout cell line (HeLa) Human KIAA0753 1:3~1:6 Negative Online Inquiry
KO32655 KIAA0753 Knockout cell line (HCT 116) Human KIAA0753 1:2~1:4 Negative Online Inquiry
KO32656 KIAA0753 Knockout cell line (HEK293) Human KIAA0753 1:3~1:6 Negative Online Inquiry
KO32657 KIAA0753 Knockout cell line (A549) Human KIAA0753 1:3~1:4 Negative Online Inquiry

Background

KIAA0753 Gene Knockout Cell Lines are sophisticated biological tools designed for in-depth genomic studies aimed at elucidating the function of the KIAA0753 gene, which has been implicated in various cellular processes, including regulation of cell proliferation and differentiation. By employing CRISPR-Cas9 technology to create these knockout lines, scientists are able to specifically disrupt gene expression, facilitating comprehensive studies into the biological pathways governed by KIAA0753.

The mechanism underlying these knockout cell lines is straightforward yet powerful; the CRISPR-Cas9 system introduces precise double-strand breaks in the DNA sequence of the KIAA0753 gene. Subsequently, the cell's natural repair mechanisms attempt to fix these breaks, often resulting in insertions or deletions (indels) that lead to the complete abrogation of normal gene function. Researchers can then assess the resulting phenotypic changes, providing critical insights into the gene's role in various cellular contexts.

The scientific importance of KIAA0753 Gene Knockout Cell Lines is underscored by their potential applications in both basic research and clinical settings. These cell lines are invaluable for investigating gene function, understanding disease mechanisms particularly in cancer research, and they can serve as a benchmark for drug screening and development efforts aimed at conditions associated with KIAA0753 dysregulation.

What sets our KIAA0753 Gene Knockout Cell Lines apart from alternative genetic tools is their reliability and specificity. Other methods may introduce off-target effects or may not provide the level of resolution required for nuanced scientific studies. Our cell lines have been rigorously validated, guaranteeing consistent performance and reproducibility in experimental outcomes, which are crucial for the advancement of scientific knowledge.

For researchers and clinicians alike, KIAA0753 Gene Knockout Cell Lines provide a cutting-edge platform that can accelerate discovery and enhance understanding in their respective fields. Their ease of use, combined with our comprehensive support and resources, positions these cell lines as an essential addition to any lab working on gene function and its implications.

As a company dedicated to advancing genomic research, we pride ourselves on delivering high-quality biological products backed by extensive scientific expertise. Our commitment to innovation ensures that researchers have access to the tools necessary to explore and unlock the complexities of the genome.

Please note that all services are for research use only. Not intended for any clinical use.

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