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KHSRP Knockout Cell Lines

Gene: KHSRP

Official Full Name: KH-type splicing regulatory proteinprovided by HGNC

Gene Summary: The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03134 KHSRP Knockout cell line (HeLa) Human KHSRP 1:3~1:6 Negative Online Inquiry
KO03135 KHSRP Knockout cell line (HCT 116) Human KHSRP 1:2~1:4 Negative Online Inquiry
KO03136 KHSRP Knockout cell line (HEK293) Human KHSRP 1:3~1:6 Negative Online Inquiry
KO03137 KHSRP Knockout cell line (A549) Human KHSRP 1:3~1:4 Negative Online Inquiry

Background

KHSRP Gene Knockout Cell Lines are sophisticated cellular models engineered to specifically disrupt the KHSRP gene, which plays a pivotal role in post-transcriptional gene regulation. By utilizing CRISPR-Cas9 technology, these cell lines possess a precise knockout of the KHSRP gene, enabling researchers to study the gene's function and its impact on various cellular processes. The disruption of KHSRP leads to altered mRNA stability and translation, which can provide insights into its involvement in disorders such as cancer, autoimmune diseases, and neurodegenerative conditions.

The key functions of KHSRP include regulation of mRNA degradation and modulation of RNA-binding protein interactions, making it crucial for the fine-tuning of gene expression. In research settings, these knockout cell lines enable scientists to explore pathways influenced by KHSRP and identify potential therapeutic targets. In clinical contexts, understanding KHSRP's functions may help in the development of novel biomarkers or treatments for diseases where mRNA regulation is disrupted.

One of the distinct advantages of the KHSRP Gene Knockout Cell Lines is their ability to provide consistent and reproducible results, owing to the complete gene disruption. This sets them apart from traditional RNA interference methods that may offer incomplete knockdown and varying levels of gene expression modulation. Additionally, these knockout lines facilitate studies on gene-gene interactions and their effects on phenotypic outcomes, providing a more comprehensive understanding of cellular dynamics.

Researchers and clinicians will find these knockout cell lines invaluable for advancing their studies, as they offer a powerful tool for gaining functional insights into gene regulation mechanisms without the confounding effects of residual gene activity. With our company’s dedication to high-quality biotechnological products and expertise in genetic engineering, we deliver exceptional tools that empower groundbreaking research and drive innovative therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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