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KDM5B Knockout Cell Lines

Gene: KDM5B

Official Full Name: lysine demethylase 5Bprovided by HGNC

Gene Summary: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09613 KDM5B Knockout cell line (HeLa) Human KDM5B 1:3~1:6 Negative Online Inquiry
KO09614 KDM5B Knockout cell line (HCT 116) Human KDM5B 1:2~1:4 Negative Online Inquiry
KO09615 KDM5B Knockout cell line (HEK293) Human KDM5B 1:3~1:6 Negative Online Inquiry
KO09616 KDM5B Knockout cell line (A549) Human KDM5B 1:3~1:4 Negative Online Inquiry

Background

KDM5B Gene Knockout Cell Lines are innovative biological tools designed to facilitate the functional study of the KDM5B gene, a critical regulator of epigenetic modifications involved in gene expression and cellular differentiation. These cell lines are engineered using CRISPR/Cas9 technology to achieve precise knockout of the KDM5B gene, allowing researchers to investigate its roles in cancer, development, and various pathologies linked to dysregulated epigenetic processes.

The primary function of these knockout cell lines revolves around the elimination of KDM5B-mediated histone demethylation, leading to altered gene expression profiles. This mechanism enables scientists to decipher the gene's impact on cellular behavior, including proliferation, apoptosis, and differentiation. Knockout of KDM5B can illustrate how this protein influences oncogenic pathways and contributes to therapeutic responses, making it invaluable for both basic and translational research.

The scientific importance of KDM5B Gene Knockout Cell Lines extends to their diverse applications in drug discovery, genetic modeling of diseases, and understanding the translational relevance of epigenetic targets in human health. They offer a unique opportunity to develop precise therapeutic interventions aimed at modulating KDM5B activity, which may hold promise for treating cancer and other disorders linked to epigenetic misregulation.

Compared to conventional approaches such as RNA interference and chemical inhibitors, these knockout cell lines provide a more permanent and specific alteration of the target gene expression. This specificity mitigates off-target effects and allows for more reliable interpretation of results, enhancing the robustness of experimental conclusions.

For researchers and clinicians seeking innovative solutions, KDM5B Gene Knockout Cell Lines deliver unmatched value by enabling cutting-edge investigations into gene function and disease mechanisms. Furthermore, they are supported by the expertise of our company, which specializes in developing high-quality biological products that empower scientific discovery and clinical advancements across multiple fields. Our commitment to excellence ensures that you receive not only exceptional products but also comprehensive support throughout your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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