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KDM4D Knockout Cell Lines

Gene: KDM4D

Official Full Name: lysine demethylase 4Dprovided by HGNC

Gene Summary: Enables histone H3K9me2/H3K9me3 demethylase activity. Involved in inflammatory response. Acts upstream of or within several processes, including cellular response to ionizing radiation; double-strand break repair via homologous recombination; and positive regulation of double-strand break repair via nonhomologous end joining. Located in site of double-strand break. Biomarker of nephroblastoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09531 KDM4D Knockout cell line (HCT 116) Human KDM4D 1:2~1:4 Negative Online Inquiry
KO09532 KDM4D Knockout cell line (HEK293) Human KDM4D 1:3~1:6 Negative Online Inquiry

Background

KDM4D Gene Knockout Cell Lines represent a cutting-edge biotechnological tool designed to facilitate in-depth investigation of the KDM4D gene, which encodes a histone demethylase involved in the regulation of gene expression and epigenetic modifications. By employing CRISPR/Cas9 technology, these cell lines provide a reliable method for generating precise gene knockouts, allowing researchers to study the functional consequences of KDM4D loss in various cellular contexts.

The primary mechanism of KDM4D Gene Knockout Cell Lines revolves around the targeted disruption of the KDM4D gene, leading to the abrogation of its enzymatic activity. This results in altered histone methylation patterns that can significantly influence transcriptional profiles, thereby revealing the gene's role in key cellular processes such as differentiation, proliferation, and response to stress. Such insights are crucial for understanding the intricate regulatory networks operating within eukaryotic cells.

The scientific importance of KDM4D Gene Knockout Cell Lines extends across both basic research and clinical applications. In research, they serve as invaluable models for elucidating the molecular underpinnings of diseases characterized by epigenetic dysregulation, including cancer and neurodegenerative disorders. Clinically, understanding KDM4D's role could pave the way for novel therapeutic strategies aimed at targeting epigenetic modifications.

What sets KDM4D Gene Knockout Cell Lines apart from alternative products is their meticulous design and validation, ensuring high efficiency and specificity in gene disruption. Unlike traditional gene silencing methods, such as RNA interference, which may exhibit off-target effects, these knockout cell lines guarantee a complete loss of function, making them a more reliable choice for researchers seeking definitive insights.

For researchers and clinicians alike, KDM4D Gene Knockout Cell Lines represent a valuable resource, enabling the exploration of gene function with unprecedented precision. Their application can enhance our understanding of complex diseases and drive the development of innovative therapeutic approaches.

Our company is dedicated to delivering top-tier biological products, underpinned by rigorous research and development efforts, to empower scientists and clinicians in their quest for groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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