Gene: KDM3A
Official Full Name: lysine demethylase 3Aprovided by HGNC
Gene Summary: Enables histone H3K9me/H3K9me2 demethylase activity; iron ion binding activity; and nuclear androgen receptor binding activity. Involved in androgen receptor signaling pathway; formaldehyde biosynthetic process; and positive regulation of DNA-templated transcription. Located in nucleoplasm. Implicated in cervical cancer and colon cancer. Biomarker of Ewing sarcoma; hepatocellular carcinoma; nasopharynx carcinoma; and prostate cancer. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07019 | KDM3A Knockout cell line (HeLa) | Human | KDM3A | 1:3~1:6 | Negative | Online Inquiry |
KO07020 | KDM3A Knockout cell line (HCT 116) | Human | KDM3A | 1:2~1:4 | Negative | Online Inquiry |
KO07021 | KDM3A Knockout cell line (HEK293) | Human | KDM3A | 1:3~1:6 | Negative | Online Inquiry |
KO07022 | KDM3A Knockout cell line (A549) | Human | KDM3A | 1:3~1:4 | Negative | Online Inquiry |
KDM3A Gene Knockout Cell Lines are customized cell lines engineered to disable the KDM3A gene, which encodes an integral histone demethylase involved in epigenetic regulation. By utilizing CRISPR/Cas9 technology, these cell lines exhibit precision editing capabilities, specifically targeting and knocking out the KDM3A gene, allowing researchers to study the gene's role in various biological processes and disease mechanisms.
The KDM3A protein is pivotal in the modulation of transcriptional regulation and cellular differentiation, impacting various pathways, including those associated with cancer, development, and metabolism. By knocking out KDM3A, researchers can delineate its contributions to disease states, enabling the identification of potential therapeutic targets. This is crucial in both basic research and translational studies, where understanding the intricacies of gene functions is essential for advancing medical science.
What sets KDM3A Gene Knockout Cell Lines apart from other genetic models is their tailored approach to gene disruption, providing high-efficiency knockout with minimal off-target effects. This specificity enhances the reliability of experimental results, making them suitable for high-throughput screening and functional assays. Furthermore, these cell lines facilitate investigations into drug-resistance mechanisms and epigenetic modifications, positioning them as invaluable tools in the burgeoning field of personalized medicine.
Researchers and clinicians can leverage the KDM3A Gene Knockout Cell Lines to gain critical insights into epigenetic regulation and its implications in human health. With our extensive expertise in cellular biology and genetic engineering, we offer this advanced product to empower scientific discovery and accelerate breakthroughs in therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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