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KCNK6 Knockout Cell Lines

Gene: KCNK6

Official Full Name: potassium two pore domain channel subfamily K member 6provided by HGNC

Gene Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33240 KCNK6 Knockout cell line (HCT 116) Human KCNK6 1:2~1:4 Negative Online Inquiry
KO33241 KCNK6 Knockout cell line (A549) Human KCNK6 1:3~1:4 Negative Online Inquiry

Background

KCNK6 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the KCNK6 gene, which encodes a potassium channel involved in various physiological processes, including neuronal excitability and cardiac function. These cell lines serve as crucial tools for researchers to investigate the roles of KCNK6 in cellular signaling pathways, ion homeostasis, and related pathophysiological conditions.

The primary function of KCNK6 Gene Knockout Cell Lines is to elucidate the consequences of the absence of KCNK6 protein. By employing CRISPR/Cas9 gene-editing technology, these cell lines exhibit a complete knockout of KCNK6, allowing for the study of altered ionic currents, changes in cellular behavior, and downstream effects on signaling pathways. Researchers can explore how the loss of KCNK6 influences cellular responses to various stimuli, thereby gaining deeper insights into its role in health and disease.

From a scientific standpoint, these knockout cell lines have diverse applications in research and clinical settings. They provide a platform for drug discovery, as potential therapeutics can be screened for efficacy against disorders linked to KCNK6 dysregulation. Furthermore, they enable the modeling of diseases such as epilepsy and cardiac arrhythmias, which are associated with potassium channel abnormalities.

KCNK6 Gene Knockout Cell Lines offer distinct advantages over traditional wild-type cell lines. Their precise genetic modification minimizes variability and enhances reproducibility, essential for rigorous scientific experimentation. Researchers benefit from the availability of validated knockout lines that reduce the time and resources invested in developing their own models, thus accelerating the pace of research.

For researchers and clinicians focused on ion channel physiology and its implications in various pathologies, KCNK6 Gene Knockout Cell Lines represent a valuable asset. They not only provide reliable models for experimentation but also enhance the understanding of KCNK6-related mechanisms, paving the way for innovative therapeutic strategies.

Our company specializes in providing high-quality genetic tools and cell lines, backed by extensive expertise in gene editing technologies. With our commitment to advancing biological research, we ensure that our products meet the highest standards of scientific rigor and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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