Home / KCNK13 Knockout Cell Lines

KCNK13 Knockout Cell Lines

Gene: KCNK13

Official Full Name: potassium two pore domain channel subfamily K member 13provided by HGNC

Gene Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16828 KCNK13 Knockout cell line (HCT 116) Human KCNK13 1:2~1:4 Negative Online Inquiry

Background

KCNK13 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack functional expression of the KCNK13 gene, which encodes for a potassium channel involved in various cellular functions, including maintaining the resting membrane potential and regulating cell excitability. These knockout models provide invaluable tools for the investigation of KCNK13's role in physiological and pathological processes, enabling researchers to dissect its contributions to various diseases, including neurological disorders and cancer.

Functionally, these cell lines exhibit altered electrophysiological properties due to the absence of KCNK13, allowing for detailed studies on how potassium ion flow influences cellular signaling and homeostasis. By utilizing these models, researchers can investigate the downstream effects of KCNK13 disruption, providing insights into ion channel pharmacology and potential therapeutic targets. The mechanism through which KCNK13 influences membrane potentials and cellular responsiveness opens a plethora of avenues for exploration in both basic and translational research.

The scientific importance of KCNK13 Gene Knockout Cell Lines cannot be overstated, as they allow for the dissection of complex cellular behaviors in a controlled environment. In clinical settings, these models can facilitate drug screening and the development of novel therapies targeting specific ion channel dysfunctions. The unique characteristics of these knockout lines provide distinct advantages over traditional cell models; they offer enhanced specificity in studying the gene's functions and potential interactions without the confounding effects present in wild-type cell lines.

For researchers and clinicians alike, the value of these knockout cell lines lies in their capacity to enable targeted research, potentially accelerating the discovery of new therapeutic approaches. Greater understanding of KCNK13's role can lead to breakthroughs in treating conditions linked to ion channel dysregulation.

Our company is deeply committed to advancing research and clinical outcomes through high-quality biological products. The KCNK13 Gene Knockout Cell Lines are a testament to our expertise in the field, delivering innovative solutions that empower scientists and clinicians to push the boundaries of knowledge in ion channel research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.