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KATNIP Knockout Cell Lines

Gene: KATNIP

Official Full Name: katanin interacting proteinprovided by HGNC

Gene Summary: This gene encodes a novel, evolutionarily conserved, ciliary protein. In human hTERT-RPE1 cells, the protein is found at the base of cilia, decorating the ciliary axoneme, and enriched at the ciliary tip. The protein binds to microtubules in vitro and regulates their stability when it is overexpressed. A null mutation in this gene has been associated with Joubert syndrome, a recessive disorder that is characterized by a distinctive mid-hindbrain and cerebellar malformation and is also often associated with wider ciliopathy symptoms. Consistently, in a serum-starvation ciliogenesis assay, human fibroblast cells derived from patients with the mutation display a reduced number of ciliated cells with abnormally long cilia. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29591 KATNIP Knockout cell line (HeLa) Human KATNIP 1:3~1:6 Negative Online Inquiry
KO29592 KATNIP Knockout cell line (HCT 116) Human KATNIP 1:2~1:4 Negative Online Inquiry
KO29593 KATNIP Knockout cell line (HEK293) Human KATNIP 1:3~1:6 Negative Online Inquiry
KO29594 KATNIP Knockout cell line (A549) Human KATNIP 1:3~1:4 Negative Online Inquiry

Background

KATNIP Gene Knockout Cell Lines represent a sophisticated tool for molecular biology research, specifically designed to facilitate the study of gene function and the pathways regulating cellular processes. These cell lines are engineered through CRISPR/Cas9 technology to achieve precise gene disruption, allowing researchers to investigate gene activity and its implications in various biological contexts.

The primary function of KATNIP Gene Knockout Cell Lines is to enable the characterization of gene knockouts, which helps elucidate gene roles in cellular mechanisms, signaling pathways, and disease states. The knockout cells provide a controlled environment to assess the loss-of-function of specific genes, aiding in the investigation of genetic contributions to health and disease. This technology leverages the efficient and targeted editing capabilities of CRISPR/Cas9, ensuring exceptional specificity and reproducibility in genetic modifications.

In the realm of scientific importance, these cell lines are invaluable in both research and clinical settings. Researchers can utilize KATNIP Gene Knockout Cell Lines to model diseases, screen for potential drug targets, and elucidate mechanisms underlying various pathologies, including cancer, metabolic disorders, and cardiovascular diseases. By offering a platform for gene silence, they contribute significantly to translational research, bridging the gap between laboratory findings and clinical applications.

What sets KATNIP Gene Knockout Cell Lines apart from conventional gene knockout models is their ease of use and adaptability across a range of experimental designs. Unlike traditional techniques that often require lengthy protocols or complex workflows, KATNIP cells simplify the process, facilitating higher throughput screenings and faster experimental turnaround times.

The value of KATNIP Gene Knockout Cell Lines is undeniable for researchers and clinicians alike. By utilizing these advanced cell lines, users can generate robust and reliable data that propel their investigations forward, ultimately leading to actionable scientific insights. The specificity and efficacy of KATNIP cell lines not only enhance research outcomes but also contribute to more effective discovery and development processes in therapeutic contexts.

At our company, we pride ourselves on our commitment to innovation and excellence in providing high-quality biological products, including our KATNIP Gene Knockout Cell Lines. Our expertise in genetic engineering and molecular biology ensures that we deliver reliable tools that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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