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KATNAL2 Knockout Cell Lines

Gene: KATNAL2

Official Full Name: katanin catalytic subunit A1 like 2provided by HGNC

Gene Summary: Predicted to enable ATP hydrolysis activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25485 KATNAL2 Knockout cell line (HCT 116) Human KATNAL2 1:2~1:4 Negative Online Inquiry
KO25486 KATNAL2 Knockout cell line (HEK293) Human KATNAL2 1:3~1:6 Negative Online Inquiry
KO25487 KATNAL2 Knockout cell line (A549) Human KATNAL2 1:3~1:4 Negative Online Inquiry

Background

KATNAL2 Gene Knockout Cell Lines are specialized cellular models developed to study the function of the KATNAL2 gene, which encodes an enzyme implicated in the regulation of microtubule dynamics and cell division. By employing CRISPR-Cas9 technology or other gene-editing methods, these cell lines have been engineered to have a complete deletion of the KATNAL2 gene, allowing researchers to explore the gene's role in various biological processes, including cell proliferation, migration, and differentiation.

The primary function of KATNAL2 gene knockout cell lines lies in their utility as an experimental tool to discern the specific contributions of the KATNAL2 gene to cellular behavior. The absence of KATNAL2 modifies microtubule stability, which can significantly affect cell mitosis and the intracellular transport processes. Through these mechanisms, researchers can gain insights into the pathophysiological implications of KATNAL2 dysregulation in cancer and neurodegenerative diseases.

Scientifically, KATNAL2 gene knockout cell lines are invaluable in both research and clinical settings. They facilitate the investigation of KATNAL2's implications in tumor biology and potential therapeutic targets. Additionally, these cell lines can serve as control models to evaluate the efficacy of drugs aiming to restore normal microtubule dynamics in affected tissues.

One of the key advantages of our KATNAL2 gene knockout cell lines over alternative models is the precision of the gene knockout, which ensures a clear understanding of the gene's role without unintended effects from residual function. Furthermore, these cell lines are extensively validated, ensuring reproducibility and reliability in experimental outcomes.

Researchers and clinicians seeking to unravel the complexities of cell behavior related to KATNAL2 will find these knockout models indispensable. They allow for targeted experimentation to explore therapeutic avenues while supporting significant advancements in our understanding of cellular mechanisms.

With a robust background in molecular biology and genetics, our company is committed to providing high-quality biological products, including KATNAL2 gene knockout cell lines, to empower the scientific community in their pursuit of knowledge and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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