Gene: KANK1
Official Full Name: KN motif and ankyrin repeat domains 1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06735 | KANK1 Knockout cell line (HeLa) | Human | KANK1 | 1:3~1:6 | Negative | Online Inquiry |
KO06736 | KANK1 Knockout cell line (HCT 116) | Human | KANK1 | 1:2~1:4 | Negative | Online Inquiry |
KO06737 | KANK1 Knockout cell line (HEK293) | Human | KANK1 | 1:3~1:6 | Negative | Online Inquiry |
KO06738 | KANK1 Knockout cell line (A549) | Human | KANK1 | 1:3~1:4 | Negative | Online Inquiry |
KANK1 Gene Knockout Cell Lines are genetically engineered human cell lines that have undergone precise deletion of the KANK1 gene, which encodes a multifunctional protein implicated in various cellular processes, including cytoskeletal organization, cell adhesion, and signal transduction. These knockout cell lines serve as critical tools for investigating the biological roles of KANK1 in health and disease, allowing researchers to dissect the molecular pathways that lead to altered physiologies or pathologies.
The primary function of the KANK1 Gene Knockout Cell Lines lies in their ability to facilitate the study of KANK1's role in cancer progression, immune response modulation, and other cellular mechanisms. By eliminating the KANK1 gene, these cell lines provide a robust system for examining the consequent phenotypic changes. Researchers can utilize these models to analyze cellular behaviors such as proliferation, migration, and invasion in a controlled environment, thus unraveling the complex network of interactions that KANK1 participates in.
Scientifically, these cell lines are invaluable in both research and clinical settings. In cancer research, for instance, KANK1 has been associated with tumor suppressive functions, making its knockout crucial for elucidating alternate pathways of tumor biology. Utilizing these models supports drug discovery and the validation of therapeutic targets aimed at modulating cancer cell behavior. Moreover, the knockout cell lines serve as essential platforms for high-throughput screening assays, enhancing the efficiency of experimental designs.
Compared to alternative genetic models, KANK1 Gene Knockout Cell Lines are created with cutting-edge CRISPR/Cas9 technology, ensuring high specificity and efficiency in gene editing. Moreover, their availability in various human cell types increases their applicability across different research contexts, providing versatility that is often lacking in traditional models.
For researchers and clinicians, the value of these knockout cell lines extends beyond mere experimentation—they represent a leap forward in our capacity to understand fundamental cellular processes and their implications in diseases. With the KANK1 Gene Knockout Cell Lines, users can accelerate their research efforts, fostering new discoveries and therapeutic approaches.
Our company specializes in the development of advanced genetic tools and cell line resources. We are committed to providing researchers with high-quality products that empower their studies and lead to groundbreaking findings in the biological sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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