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JMJD1C Knockout Cell Lines

Gene: JMJD1C

Official Full Name: jumonji domain containing 1Cprovided by HGNC

Gene Summary: The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27565 JMJD1C Knockout cell line (HeLa) Human JMJD1C 1:3~1:6 Negative Online Inquiry
KO27566 JMJD1C Knockout cell line (HCT 116) Human JMJD1C 1:2~1:4 Negative Online Inquiry
KO27567 JMJD1C Knockout cell line (HEK293) Human JMJD1C 1:3~1:6 Negative Online Inquiry
KO27568 JMJD1C Knockout cell line (A549) Human JMJD1C 1:3~1:4 Negative Online Inquiry

Background

JMJD1C Gene Knockout Cell Lines represent a pioneering tool in the field of genetic research, specifically designed to study the functional implications of the Jumonji domain-containing protein 1C (JMJD1C). These cell lines have been meticulously engineered to lack the JMJD1C gene, thereby enabling researchers to investigate the role of this histone demethylase in various biological processes, including epigenetic regulation, cellular differentiation, and metabolic pathways.

The key function of JMJD1C lies in its enzymatic activity, which demethylates histone proteins, influencing gene expression patterns crucial for numerous physiological processes. By creating knockout models, scientists can elucidate the gene's involvement in pathologies such as cancer, obesity, and neurodegenerative diseases, providing valuable insights that could inform therapeutic strategies. The mechanism by which these cell lines operate allows for high-throughput screening and functional assays, granting researchers the ability to assess JMJD1C-dependent phenotypes in diverse experimental contexts.

The scientific importance of JMJD1C Gene Knockout Cell Lines extends beyond basic research; they serve as critical platforms for drug discovery, biomarker identification, and precision medicine approaches. Traditional models may not accurately replicate the complexities of JMJD1C function, making these knockout cell lines a superior alternative for researchers seeking accurate, reproducible results.

What sets our JMJD1C Gene Knockout Cell Lines apart is their validated knockout efficiency, genetic stability, and readiness for immediate experimentation. We provide comprehensive supporting data and protocols, facilitating seamless integration into existing research workflows. Researchers and clinicians can trust these cell lines not simply as products, but as essential components of their innovation toolkit.

At [Your Company Name], we leverage advanced genomic engineering techniques to deliver high-quality biological products tailored to the needs of the research community. Our commitment to excellence ensures that every product not only meets but exceeds the expectations of researchers striving to push the boundaries of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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