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ITPRIPL1 Knockout Cell Lines

Gene: ITPRIPL1

Official Full Name: ITPRIP like 1provided by HGNC

Gene Summary: Enables receptor ligand activity. Involved in negative regulation of T cell receptor signaling pathway. Located in membrane. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22027 ITPRIPL1 Knockout cell line (HCT 116) Human ITPRIPL1 1:2~1:4 Negative Online Inquiry
KO22028 ITPRIPL1 Knockout cell line (HEK293) Human ITPRIPL1 1:3~1:6 Negative Online Inquiry

Background

ITPRIPL1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the expression of the Inositol 1,4,5-Trisphosphate Receptor Interacting Protein Like 1 (ITPRIPL1) gene. This gene plays a significant role in cellular signaling pathways, particularly in the regulation of calcium homeostasis and intracellular signaling functions. The knockout of ITPRIPL1 provides a powerful tool for researchers aiming to elucidate the specific contributions of this protein in various physiological and pathological contexts.

These cell lines function by delving into the consequences of ITPRIPL1 absence, allowing scientists to investigate the downstream effects on calcium signaling, cell proliferation, and apoptosis. Utilizing CRISPR/Cas9 technology or other gene-editing methods, the resultant cell lines exhibit a clear and reproducible phenotype, making them invaluable for functional studies. The meticulous validation and characterization of these knockouts ensure that researchers can confidently interpret their findings in various experimental paradigms.

The scientific importance of ITPRIPL1 Gene Knockout Cell Lines cannot be overstated. They are essential in research fields such as neurobiology, cardiovascular diseases, and cancer biology, where the roles of calcium signaling and cellular homeostasis are critical. Additionally, these cell lines present opportunities in drug development, allowing for screenings that can identify compounds targeting specific pathways influenced by ITPRIPL1.

What sets these knockout cell lines apart from alternative models is their specificity and reliability. Unlike broad-spectrum inhibitors or general knockdown approaches that may yield ambiguous results, our ITPRIPL1 knockout models provide precise control over gene expression, ensuring that researchers can draw accurate conclusions about the role of the ITPRIPL1 protein.

For researchers and clinicians, the value of ITPRIPL1 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries and therapeutic advancements. As our understanding of calcium signaling continues to evolve, these cell lines represent a cornerstone resource that paves the way for innovative research.

Our company is dedicated to providing high-quality and rigorously validated biological products, and our ITPRIPL1 Gene Knockout Cell Lines exemplify our commitment to advancing scientific inquiry and discovery. With extensive expertise in cellular models, we are poised to support pioneering research in the biomedical community.

Please note that all services are for research use only. Not intended for any clinical use.

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