Gene: ITGB8
Official Full Name: integrin subunit beta 8provided by HGNC
Gene Summary: This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10276 | ITGB8 Knockout cell line (HeLa) | Human | ITGB8 | 1:3~1:6 | Negative | Online Inquiry |
KO10277 | ITGB8 Knockout cell line (HCT 116) | Human | ITGB8 | 1:2~1:4 | Negative | Online Inquiry |
KO10278 | ITGB8 Knockout cell line (HEK293) | Human | ITGB8 | 1:3~1:6 | Negative | Online Inquiry |
ITGB8 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate in-depth studies of the integrin beta 8 (ITGB8) gene, a critical component involved in cell adhesion and signaling pathways. These cell lines are created through targeted gene editing techniques, such as CRISPR/Cas9, rendering them deficient in the ITGB8 gene. This knockout approach allows researchers to investigate the biological implications of ITGB8's absence on various cellular processes, including proliferation, migration, and extracellular matrix interactions.
The primary function of these cell lines is to serve as a model system for elucidating the role of ITGB8 in physiological and pathological contexts. By utilizing these knockout lines, scientists can directly assess how the loss of ITGB8 influences disease progression, such as in cancer metastasis, wound healing, or fibrosis, thereby providing insights into potential therapeutic interventions. Moreover, these cell lines can be used in drug discovery and development, contributing valuable data on how the modulation of integrin pathways can affect cellular behavior.
One of the distinct advantages of our ITGB8 Gene Knockout Cell Lines over alternatives, such as traditional wild-type cell lines or less specific knockdown models, is their precise genetic modification, which leads to a more accurate representation of the biological consequences of ITGB8 loss. These cell lines offer researchers the ability to reproduce the loss-of-function studies more reliably and obtain reproducible results, making them a critical tool for both basic and applied biological research.
Offering unparalleled specificity and reliability, our ITGB8 Gene Knockout Cell Lines are indispensable for researchers and clinicians seeking to deepen their understanding of integrin biology and its implications in various diseases. The insights gained from studies incorporating these cell lines can ultimately lead to novel therapeutic strategies, highlighting their significance in advancing biomedical research.
We are committed to delivering high-quality, scientifically validated products that empower researchers in their quest for knowledge. Our expertise in genetic engineering and cell line development ensures that customers receive reliable and robust tools to support their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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