Gene: ITGB1BP2
Official Full Name: integrin subunit beta 1 binding protein 2provided by HGNC
Gene Summary: This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28050 | ITGB1BP2 Knockout cell line (HeLa) | Human | ITGB1BP2 | 1:3~1:6 | Negative | Online Inquiry |
KO28051 | ITGB1BP2 Knockout cell line (HCT 116) | Human | ITGB1BP2 | 1:2~1:4 | Negative | Online Inquiry |
KO28052 | ITGB1BP2 Knockout cell line (HEK293) | Human | ITGB1BP2 | 1:3~1:6 | Negative | Online Inquiry |
KO28053 | ITGB1BP2 Knockout cell line (A549) | Human | ITGB1BP2 | 1:3~1:4 | Negative | Online Inquiry |
ITGB1BP2 Gene Knockout Cell Lines represent a revolutionary tool for molecular biology research, specifically targeting the integrin β1-binding protein 2 (ITGB1BP2) gene, which plays a critical role in cell adhesion and signaling. These custom-generated knockout cell lines utilize CRISPR-Cas9 technology to precisely edit the ITGB1BP2 gene, leading to complete gene disruption. By ceasing the expression of this gene, researchers can investigate its contributions to various cellular processes, including migration, proliferation, and interaction with the extracellular matrix.
The primary function of these knockout cell lines is to facilitate the study of the ITGB1BP2 pathway and its involvement in critical signaling cascades, particularly in the context of cancer biology and regenerative medicine. The elucidation of these pathways is paramount for understanding tumor metastasis and developing innovative therapeutic approaches. Importantly, these knockout cell lines provide researchers with a robust system to investigate gene function, decipher molecular mechanisms, and evaluate drug responses under controlled conditions.
The scientific importance of ITGB1BP2 Gene Knockout Cell Lines is evident in their applications across fundamental research and translational studies. They are invaluable for studying diseases associated with integrin dysfunction and can serve as models for evaluating the potential effects of drug candidates targeting integrin-mediated pathways, thereby accelerating the drug discovery process.
What sets our ITGB1BP2 Gene Knockout Cell Lines apart from alternatives on the market is their precision and the comprehensive support from our experienced scientific team. Each cell line is validated for effective knockout efficiency and functionality, ensuring reliability for any experimental design. Additionally, our commitment to providing detailed documentation and troubleshooting guidance enhances the user experience, enabling researchers to achieve their objectives more efficiently.
In a landscape where understanding cellular behavior is crucial for breakthroughs in medical research, ITGB1BP2 Gene Knockout Cell Lines are an indispensable asset for researchers and clinicians alike. Our company boasts a wealth of experience in genetic engineering and cell line development, reflecting our dedication to delivering high-quality biological products that empower scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.