Gene: ITGA7
Official Full Name: integrin subunit alpha 7provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10295 | ITGA7 Knockout cell line (HeLa) | Human | ITGA7 | 1:3~1:6 | Negative | Online Inquiry |
KO10296 | ITGA7 Knockout cell line (HCT 116) | Human | ITGA7 | 1:2~1:4 | Negative | Online Inquiry |
KO10297 | ITGA7 Knockout cell line (HEK293) | Human | ITGA7 | 1:3~1:6 | Negative | Online Inquiry |
KO10298 | ITGA7 Knockout cell line (A549) | Human | ITGA7 | 1:3~1:4 | Negative | Online Inquiry |
ITGA7 Gene Knockout Cell Lines are genetically modified cell lines in which the gene encoding the integrin alpha-7 subunit (ITGA7) has been disrupted, providing a crucial tool for researchers studying muscle biology and associated diseases. Integrins are vital transmembrane receptors that mediate cell-extracellular matrix adhesion, and the alpha-7 integrin is particularly important in skeletal muscle development and regeneration. By generating ITGA7 knockout cell lines, researchers are able to investigate the specific roles of this integrin in cellular processes such as differentiation, migration, and cellular signaling pathways that influence muscle maintenance and repair.
The primary function of ITGA7 is to facilitate cell adhesion to the extracellular matrix, thus influencing muscle cell behavior. In the absence of ITGA7, these cell lines exhibit altered adhesive properties, cellular morphology, and signaling dynamics, allowing for in-depth studies into the mechanisms of muscular dystrophies and other myopathies. Researchers can leverage these models to understand disease pathology and test therapeutic strategies aimed at restoring normal muscle function.
The scientific importance of ITGA7 Gene Knockout Cell Lines extends to various applications in both basic and translational research settings, including pharmaceutical drug screening and gene therapy studies. They serve as a platform for examining the effects of potential treatments for muscle-related disorders, making them invaluable for both academic and clinical research environments.
What sets our ITGA7 Gene Knockout Cell Lines apart from other alternatives in the market are their consistent performance and the meticulous validation processes used during their development. Each cell line is extensively characterized for knockout efficiency and functional assays, ensuring high reliability in experimental setups.
For researchers and clinicians, these cell lines offer a unique opportunity to advance their studies on muscle health and disease, enhancing potential therapeutic outcomes. By utilizing our ITGA7 Gene Knockout Cell Lines, users can access robust, scientifically validated resources conducive to pioneering discoveries in muscle biology.
Our company prides itself on its commitment to quality and innovation in the field of biological products. With a strong foundation in molecular biology and cell line technology, we provide comprehensive solutions that empower researchers to achieve their scientific goals effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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