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ITGA5 Knockout Cell Lines

Gene: ITGA5

Official Full Name: integrin subunit alpha 5provided by HGNC

Gene Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00602 ITGA5 Knockout cell line(A549) Human ITGA5 1:3~1:4 Negative Online Inquiry
KO10303 ITGA5 Knockout cell line (HeLa) Human ITGA5 1:3~1:6 Negative Online Inquiry
KO10304 ITGA5 Knockout cell line (HCT 116) Human ITGA5 1:2~1:4 Negative Online Inquiry
KO10305 ITGA5 Knockout cell line (HEK293) Human ITGA5 1:3~1:6 Negative Online Inquiry

Background

ITGA5 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the Integrin Alpha 5 (ITGA5) gene, a key component of extracellular matrix interactions. These cell lines serve as vital tools for researchers investigating cellular attachment, migration, and signaling pathways integral to tissue development and disease progression. By removing the ITGA5 gene, these cell lines provide insight into how cells interact with their microenvironment and the role this interaction plays in various biological processes.

The primary function of the ITGA5 Gene Knockout Cell Lines is to mimic conditions where ITGA5 is absent, allowing researchers to study the effects of this integrin's absence on cell behavior. Through various assays, including cell adhesion, proliferation, and migration studies, researchers can elucidate the signaling pathways influenced by ITGA5. Moreover, these cell lines help in investigating the contributions of integrin signaling in cancer metastasis, wound healing, and fibrosis, all of which are fundamental areas of research in cellular biology and therapeutic development.

The scientific importance of ITGA5 Knockout Cell Lines lies in their ability to provide a controlled environment for studying integrin functions and their implications in health and disease. These models facilitate the identification of novel therapeutic targets and potential biomarker discovery in oncology and regenerative medicine.

Compared to traditional cell lines, these knockout models offer superior specificity, eliminating off-target effects and allowing for clearer interpretation of experimental data. This precision can significantly enhance the credibility of research findings, making ITGA5 Gene Knockout Cell Lines an invaluable asset in both academic and clinical research.

Research scientists and clinicians benefit from these cell lines, as they enable more focused studies on integrin-related pathways, leading to breakthroughs in understanding disease mechanisms and developing targeted therapies. The potential to refine experimental designs and obtain clearer insights into cellular dynamics significantly boosts the utility of this product.

Our company specializes in providing high-quality biological products, including cutting-edge gene knockout cell lines, backed by extensive expertise in genetic engineering and cell biology. We are committed to supporting the scientific community with products that advance research and innovation in multiple fields.

Please note that all services are for research use only. Not intended for any clinical use.

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