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ISG20 Knockout Cell Lines

Gene: ISG20

Official Full Name: interferon stimulated exonuclease gene 20provided by HGNC

Gene Summary: Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37028 ISG20 Knockout cell line (HeLa) Human ISG20 1:3~1:6 Negative Online Inquiry
KO37029 ISG20 Knockout cell line (HCT 116) Human ISG20 1:2~1:4 Negative Online Inquiry
KO37030 ISG20 Knockout cell line (A549) Human ISG20 1:3~1:4 Negative Online Inquiry

Background

ISG20 Gene Knockout Cell Lines are engineered cellular models designed to facilitate in-depth research into the immunological and cellular functions associated with the ISG20 gene. ISG20 is known for its role in the antiviral response and its involvement in various cellular processes, including apoptosis and RNA metabolism. By creating knockout cell lines that completely lack ISG20 expression, researchers can investigate the gene's specific contributions to immune signaling pathways and the overall cellular response to viral infections.

The key mechanism behind the ISG20 Gene Knockout Cell Lines is the targeted gene disruption utilizing CRISPR-Cas9 technology, which allows for precise editing of the genetic material. This method ensures that the resulting cell lines serve as robust models for examining the consequences of ISG20 absence on cellular behavior. The versatility of this approach enables researchers to study ISG20's implications in viral pathogenesis, immune modulation, and potential therapeutic targets for a variety of diseases.

From a scientific standpoint, these knockout cell lines hold significant value in both biomedical research and clinical investigations. They can be utilized to elucidate the pathogenic mechanisms of viruses, assess potential gene therapy strategies, and screen for antiviral compounds. The absence of ISG20 provides a unique opportunity to understand its role in the innate immune response, contributing to the development of innovative therapeutic approaches.

Compared to alternative models that may not accurately capture the effects of gene knockout, the ISG20 Gene Knockout Cell Lines offer unparalleled specificity, reproducibility, and ease of use. These cell lines are thoroughly validated, ensuring consistency and reliability in experimental outcomes. Moreover, they are compatible with high-throughput screening applications, making them an ideal choice for researchers aiming to accelerate their studies.

By utilizing ISG20 Gene Knockout Cell Lines, researchers and clinicians can gain critical insights into the dynamics of immune responses, facilitating advancements in therapeutic interventions. Our company prides itself on its expertise in developing cutting-edge biological models, and the ISG20 Gene Knockout Cell Lines exemplify our commitment to providing high-quality tools that empower scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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