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ISG15 Knockout Cell Lines

Gene: ISG15

Official Full Name: ISG15 ubiquitin like modifierprovided by HGNC

Gene Summary: The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00201 ISG15 Knockout cell line (THP-1) Human ISG15 1:2-1:4 Negative Online Inquiry
KO00992 ISG15 Knockout cell line (A549) Human ISG15 1:3~1:4 Negative Online Inquiry
KO05033 ISG15 Knockout cell line (HeLa) Human ISG15 1:3~1:6 Negative Online Inquiry
KO05034 ISG15 Knockout cell line (HCT 116) Human ISG15 1:2~1:4 Negative Online Inquiry
KO05035 ISG15 Knockout cell line (HEK293) Human ISG15 1:3~1:6 Negative Online Inquiry

Background

ISG15 Gene Knockout Cell Lines are specialized cell lines engineered to lack the interferon-stimulated gene 15 (ISG15), a ubiquitin-like molecule involved in various cellular processes, including immune response regulation, viral defense, and inflammation. These knockout cell lines provide a crucial tool for researchers to dissect the molecular pathways regulated by ISG15, allowing for comprehensive studies of its role in both health and disease.

The key function of ISG15 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of ISG15's impact on signaling pathways and cellular responses to stress and infection. By analyzing the differences in behavior, gene expression, and protein interactions between knockout and wild-type cell lines, scientists can uncover the distinct contributions of ISG15 to immune modulation and identify potential avenues for therapeutic intervention in autoimmune diseases or viral infections.

The scientific importance of these cell lines extends into both research and clinical settings. They are invaluable for studying diseases where ISG15 is implicated, such as certain cancers and viral pathologies, thereby providing insights into disease mechanisms and potential drug targets. Furthermore, they serve as a platform for the development of ISG15-targeted therapies, making them a vital component of translational research.

Compared to alternative models, ISG15 Gene Knockout Cell Lines offer a precise and tailored approach to studying ISG15 function, allowing for controlled experimentation without the confounding effects of ISG15 activity. This specificity enhances the reliability of research findings and supports the development of targeted therapies.

For researchers and clinicians, the value of ISG15 Gene Knockout Cell Lines is immeasurable. They not only deepen our understanding of the immune response but also pave the way for breakthroughs in treatment strategies for diseases characterized by dysregulated immune signaling. Backed by our company's proven expertise in producing high-quality biological products, we are committed to advancing research and development initiatives through our innovative offerings, including the ISG15 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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