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IQSEC2 Knockout Cell Lines

Gene: IQSEC2

Official Full Name: IQ motif and Sec7 domain ArfGEF 2provided by HGNC

Gene Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29868 IQSEC2 Knockout cell line (HeLa) Human IQSEC2 1:3~1:6 Negative Online Inquiry
KO29869 IQSEC2 Knockout cell line (HCT 116) Human IQSEC2 1:2~1:4 Negative Online Inquiry
KO29870 IQSEC2 Knockout cell line (HEK293) Human IQSEC2 1:3~1:6 Negative Online Inquiry
KO29871 IQSEC2 Knockout cell line (A549) Human IQSEC2 1:3~1:4 Negative Online Inquiry

Background

IQSEC2 Gene Knockout Cell Lines are meticulously engineered biological tools designed to facilitate the study of IQSEC2 gene function and its associated pathways. These cell lines are generated through the CRISPR-Cas9 gene-editing technology, enabling precise disruption of the IQSEC2 gene, which plays a pivotal role in intracellular signaling and synaptic organization in the nervous system.

The principal mechanism of action involves the targeted deletion of the IQSEC2 gene, leading to the ablation of its protein product. This knockout model allows researchers to investigate the downstream effects of IQSEC2 loss on cellular processes and signaling pathways, particularly those related to synaptic transmission and neurodevelopment. The resulting phenotypic alterations can provide valuable insights into the gene's contributions to neurological disorders and cognitive functions.

In the realm of scientific research, IQSEC2 gene knockout cell lines are essential for elucidating the molecular mechanisms underlying various neuropsychiatric conditions such as intellectual disabilities and autism spectrum disorders. They serve as vital tools for drug discovery and the development of therapeutic strategies targeting signaling pathways associated with IQSEC2.

What sets IQSEC2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, coupled with the ease of use in a variety of experimental setups. Unlike traditional knockout models that may have off-target effects or variable expression levels, these cell lines ensure consistent gene disruption, enabling reproducible results across different research applications.

For researchers and clinicians aiming to advance their understanding of neurobiology, the IQSEC2 Gene Knockout Cell Lines offer unparalleled insight into gene function and disease mechanisms. By utilizing these state-of-the-art models, users can confidently engage in groundbreaking research that has the potential to drive innovation in therapeutic interventions.

Our company specializes in providing high-quality biological products that empower researchers in their quest for scientific excellence. With expertise in advanced genomic technologies and a commitment to reliability, we ensure that our offerings meet the highest standards of quality.

Please note that all services are for research use only. Not intended for any clinical use.

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