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IQSEC1 Knockout Cell Lines

Gene: IQSEC1

Official Full Name: IQ motif and Sec7 domain ArfGEF 1provided by HGNC

Gene Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Located in nucleolus. Implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32512 IQSEC1 Knockout cell line (HeLa) Human IQSEC1 1:3~1:6 Negative Online Inquiry
KO32513 IQSEC1 Knockout cell line (HCT 116) Human IQSEC1 1:2~1:4 Negative Online Inquiry
KO32514 IQSEC1 Knockout cell line (HEK293) Human IQSEC1 1:3~1:6 Negative Online Inquiry
KO32515 IQSEC1 Knockout cell line (A549) Human IQSEC1 1:3~1:4 Negative Online Inquiry

Background

IQSEC1 Gene Knockout Cell Lines are a groundbreaking tool in molecular biology designed to facilitate the study of IQSEC1 gene function and its implications in various biological pathways and diseases. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to achieve precise disruption of the IQSEC1 gene, allowing researchers to analyze the resulting phenotypic changes and gain deeper insights into the biological mechanisms driven by this gene.

The primary function of IQSEC1 involves its role as a guanine nucleotide exchange factor (GEF) that modulates signaling pathways related to neuronal function, synaptic plasticity, and cytoskeletal dynamics. By utilizing these knockout cell lines, scientists can extensively investigate the perturbations in these pathways, thereby enhancing our understanding of neurodevelopmental disorders and other pathologies linked to dysregulated IQSEC1 activity.

In terms of scientific importance, IQSEC1 Gene Knockout Cell Lines provide a robust model for research in both fundamental biology and applied clinical health sciences. Their ability to mimic disease states makes them invaluable for drug discovery, target validation, and the development of therapeutic interventions aimed at conditions such as intellectual disability and autism spectrum disorders, which have been associated with mutations in the IQSEC1 gene.

What sets these cell lines apart from traditional models is their specific targeting and ease of use, allowing for rapid results with high reproducibility. Their applicability spans a range of research applications without the confounding effects often observed in whole-organism studies. Moreover, these knockout lines save researchers time and resources by providing a more efficient alternative to developing their models from scratch.

For researchers and clinicians focused on unraveling the complexities of IQSEC1 and its associated pathways, these cell lines represent not just a product, but a significant advancement in biological research capabilities. Our company, leveraging extensive expertise in gene editing technologies and molecular biology, is proud to provide high-quality IQSEC1 Gene Knockout Cell Lines that empower the scientific community to push the boundaries of knowledge in this critical area of research.

Please note that all services are for research use only. Not intended for any clinical use.

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