Gene: ING4
Official Full Name: inhibitor of growth family member 4provided by HGNC
Gene Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22931 | ING4 Knockout cell line (HeLa) | Human | ING4 | 1:3~1:6 | Negative | Online Inquiry |
KO22932 | ING4 Knockout cell line (HCT 116) | Human | ING4 | 1:2~1:4 | Negative | Online Inquiry |
KO22933 | ING4 Knockout cell line (HEK293) | Human | ING4 | 1:3~1:6 | Negative | Online Inquiry |
KO22934 | ING4 Knockout cell line (A549) | Human | ING4 | 1:3~1:4 | Negative | Online Inquiry |
ING4 Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the ING4 gene. This gene is crucial in the regulation of various cellular processes, including cell cycle progression, apoptosis, and transcriptional regulation. By utilizing CRISPR-Cas9 technology, these cell lines enable researchers to study the specific functions and downstream effects of the ING4 gene in a controlled environment. Upon knockout, researchers can observe alterations in cellular behavior and gene expression patterns, providing insights into the gene's role in oncogenesis and other pathophysiological conditions.
The key functions of these cell lines lie in their ability to facilitate comprehensive studies on the impact of ING4 absence. This includes understanding its involvement in cancer biology, where ING4 is known to exhibit tumor-suppressor properties. The knockout of this gene can elucidate pathways affecting cellular proliferation and survival, thereby offering a model for targeted therapeutic strategies.
In scientific research and clinical settings, ING4 Gene Knockout Cell Lines are invaluable for drug discovery, functional genomics, and the exploration of molecular mechanisms underlying diseases. The ability to study gene function in a knockout context allows for enhanced clarity in experimental results, which can lead to significant breakthroughs in understanding how ING4 operates within various biological pathways.
Compared to alternative models that may only provide partial insights, these knockout cell lines offer a precise, gene-specific approach to exploration, ensuring that findings are directly attributable to the lack of ING4 function. Moreover, they are easier to manipulate for downstream applications such as RNA sequencing or proteomics, making them a comprehensive tool for modern biological research.
Ultimately, ING4 Gene Knockout Cell Lines represent a compelling option for researchers and clinicians focused on cancer studies and related fields. They provide a unique platform that combines precision with the potential for impactful discoveries. Our company, recognized for its commitment to cutting-edge biological products, is dedicated to delivering high-quality, innovative research tools that empower the scientific community to enhance their understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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