Gene: ING1
Official Full Name: inhibitor of growth family member 1provided by HGNC
Gene Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37052 | ING1 Knockout cell line (HeLa) | Human | ING1 | 1:3~1:6 | Negative | Online Inquiry |
KO37053 | ING1 Knockout cell line (HCT 116) | Human | ING1 | 1:2~1:4 | Negative | Online Inquiry |
KO37054 | ING1 Knockout cell line (HEK293) | Human | ING1 | 1:3~1:6 | Negative | Online Inquiry |
KO37055 | ING1 Knockout cell line (A549) | Human | ING1 | 1:3~1:4 | Negative | Online Inquiry |
ING1 Gene Knockout Cell Lines are specialized biological models engineered to lack the expression of the Inhibitor of Growth Protein 1 (ING1) gene. This product facilitates the study of various cellular processes, including apoptosis, cell cycle regulation, and stress response mechanisms by providing a controlled environment to assess the functional consequences of ING1 deficiency. The knockout cell lines are derived from well-characterized parental cell lines, ensuring reliability and reproducibility in experimental outcomes.
The primary function of ING1 involves its role as a tumor suppressor and regulator of gene expression, particularly in response to DNA damage and cellular stress. By inhibiting cell proliferation and promoting apoptotic pathways, the loss of ING1 can affect tumorigenesis and overall cell health. Researchers can utilize these knockout cell lines to explore the downstream effects of ING1 loss, evaluate therapeutic targets, and elucidate the molecular pathways involved in cancer development and progression.
The scientific importance of ING1 Gene Knockout Cell Lines extends to multiple research fields, including oncology, molecular biology, and genetics. These models are invaluable for identifying potential drug candidates, designing targeted therapies, and conducting mechanistic studies related to cancer biology. Their application in preclinical studies can enhance our understanding of tumor-suppressive networks and contribute to the development of innovative cancer treatments.
One of the key advantages of using our ING1 Gene Knockout Cell Lines is their validation and standardization, enabling consistent performance across various experimental conditions. Unlike alternative models, our lines come with comprehensive characterization data, ensuring that researchers can trust the authenticity of their findings. Additionally, the ease of use and adaptability to common laboratory assays such as CRISPR/Cas9 gene editing technology make these cell lines an essential tool for any molecular biology lab.
Researchers and clinicians seeking to advance their understanding of tumor biology or develop new therapeutic strategies will find immense value in our ING1 Gene Knockout Cell Lines. The unique combination of validated gene editing and biological relevance supports groundbreaking research endeavors, ultimately contributing to our quest to better understand and combat cancer.
Our company prides itself on its long-standing commitment to providing high-quality, reliable biological products. Leveraging advanced techniques and a deep understanding of cellular mechanisms, we offer unmatched expertise in developing models that push the boundaries of scientific exploration. By choosing our products, you are partnering with a leader in biological research solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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