IL4I1 Knockout Cell Lines

Gene: IL4I1

Official Full Name: interleukin 4 induced 1provided by HGNC

Gene Summary: This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
GP00263	IL4I1 gRNA1-gRNA2 KO plasmid		IL4I1			$850
KO00644	IL4I1 Knockout cell line(MDA-MB-231)	Human	IL4I1	1:2~1:4	Negative	Online Inquiry

Background

IL4I1 Gene Knockout Cell Lines are genetically engineered cell lines in which the IL4I1 gene—associated with immune response regulation—has been inactivated. This innovative biological product enables researchers to study the IL4I1 gene's function and delineate its role in various immunological processes. The knockout mechanism is typically achieved through CRISPR-Cas9 technology, allowing for precise edits that result in the complete knockout of the target gene, confirming its absence through both molecular and phenotypic analyses.

The key function of IL4I1 is its involvement in immune regulation, specifically through the modulation of T cell responses and the promotion of immune tolerance. By utilizing these knockout cell lines, researchers can elucidate the biological pathways influenced by IL4I1, contributing to a deeper understanding of diseases such as cancer and autoimmune disorders. The implications of studying IL4I1 in these contexts are significant, making these cell lines valuable tools in both exploratory research and the development of therapeutic strategies.

Compared to alternative models, IL4I1 Gene Knockout Cell Lines offer the unique advantage of precise knockout without off-target effects, thus providing reliable data for researchers investigating immune responses. Furthermore, they facilitate the study of gene function in a controlled setting, which is critical for advancing our understanding of cellular processes under physiological and pathological conditions.

This product's value lies not only in its ability to advance scientific knowledge but also in its potential to lead to novel therapeutic interventions. Researchers and clinicians can leverage these knockout cell lines to experiment with new treatments aimed at modulating immune responses, ultimately benefiting patient care.

Our company boasts expertise in genetic engineering and cell line development, providing high-quality products that meet rigorous scientific standards. With our commitment to excellence, we empower the scientific community to achieve breakthroughs in understanding biological systems and enhancing human health.

Please note that all services are for research use only. Not intended for any clinical use.

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