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IL20RB Knockout Cell Lines

Gene: IL20RB

Official Full Name: interleukin 20 receptor subunit betaprovided by HGNC

Gene Summary: IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11267 IL20RB Knockout cell line (HeLa) Human IL20RB 1:3~1:6 Negative Online Inquiry
KO11268 IL20RB Knockout cell line (HCT 116) Human IL20RB 1:2~1:4 Negative Online Inquiry
KO11269 IL20RB Knockout cell line (A549) Human IL20RB 1:3~1:4 Negative Online Inquiry

Background

IL20RB Gene Knockout Cell Lines are expertly crafted biological tools designed to facilitate the study of the IL-20 receptor subunit, a critical component involved in inflammatory responses and immune regulation. These cell lines have been genetically modified to lack the IL20RB gene, allowing researchers to explore the role of IL-20 signaling in various cellular processes and diseases. By effectively eliminating the receptor’s function, scientists can assess how this disruption impacts pathways associated with inflammation, fibrosis, and autoimmune disorders.

The primary mechanism behind the IL20RB Gene Knockout Cell Lines centers on the precise knockout of the IL20RB gene through targeted CRISPR-Cas9 technology. This gene editing methodology ensures a high degree of specificity and efficiency, yielding stable cell lines that exhibit predictable phenotypic characteristics. Researchers can employ these cell lines in drug screening, biomarker discovery, and mechanistic studies, particularly in the context of therapeutic interventions aimed at modulating the immune system.

The scientific relevance of IL20RB Gene Knockout Cell Lines extends beyond basic research; they hold significant applications in translational medicine. Understanding the interactions of IL-20 with its receptors can lead to the development of targeted therapies for diseases characterized by dysregulated immune responses, such as psoriasis and rheumatoid arthritis. Moreover, these cell lines provide an invaluable model for investigating the role of IL-20 in cancer biology, potentially unveiling novel treatment opportunities.

What sets our IL20RB Gene Knockout Cell Lines apart from conventional alternatives is their unparalleled precision and reliability. By utilizing high-fidelity gene editing techniques, we ensure minimal off-target effects and robust lineage stability, making these lines ideal for both in vitro and in vivo studies. Additionally, our cell lines are rigorously validated through molecular characterization, granting researchers confidence in their experimental outcomes.

For researchers and clinicians, the IL20RB Gene Knockout Cell Lines offer an essential means to advance understanding in immune system modulation and therapeutic innovation. By employing these sophisticated models, users can unlock novel insights that drive breakthroughs in treatment and diagnostics. Our company is committed to empowering scientific advancement with high-quality biological products grounded in meticulous research, vast expertise, and a passion for innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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