Gene: IL1RL2
Official Full Name: interleukin 1 receptor like 2provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33839 | IL1RL2 Knockout cell line (HeLa) | Human | IL1RL2 | 1:3~1:6 | Negative | Online Inquiry |
IL1RL2 Gene Knockout Cell Lines are genetically modified cell lines in which the IL1RL2 gene has been inactivated, allowing for the study of the gene's role in various biological processes and diseases. IL1RL2, also known as IL-1 receptor-like 2, is a receptor that plays a critical role in the immune response and has been implicated in inflammatory diseases, allergies, and certain malignancies. By utilizing knockout cell lines, researchers can observe the effects of the absence of this receptor in cellular assays, thereby providing valuable insight into its physiological and pathological functions.
These cell lines function by being deficient in IL1RL2 expression, which can alter the signaling pathways associated with immune activation and inflammation. The absence of IL1RL2 allows scientists to elucidate its relationship with other cytokines and immune mediators, as well as its potential contributions to diseases such as asthma and rheumatoid arthritis. Such studies are crucial for understanding the underlying mechanisms of disease and for the development of targeted therapies.
The scientific importance of IL1RL2 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical trials. They serve as essential tools in drug discovery and testing, particularly in validating the efficacy of IL1RL2-targeted therapies and evaluating their safety profiles in preclinical studies.
Unique to our product line, these cell lines are generated using cutting-edge CRISPR/Cas9 gene-editing technology, ensuring high precision and reproducibility in knockout efficiency. Additionally, we provide comprehensive characterization and validation data, which is not always available from alternative suppliers. This ensures that researchers can trust the fidelity of their experimental outcomes.
For researchers, clinicians, and pharmaceutical companies looking to deepen their understanding of IL1RL2's role in health and disease, these knockout cell lines offer an invaluable resource. By choosing our IL1RL2 Gene Knockout Cell Lines, users are investing in quality, consistency, and innovation rooted in our commitment to advancing scientific discovery. Our expertise in genetic engineering and robust quality control processes position us as a leader in the field of biological products, dedicated to supporting your research and therapeutic goals.
Please note that all services are for research use only. Not intended for any clinical use.
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