Gene: IKBKG
Official Full Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by HGNC
Gene Summary: This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00169 | IKBKG gRNA3-gRNA4 KO plasmid | IKBKG | $850 | |||
KO00566 | IKBKG knockout cell line (HeLa) | Human | IKBKG | 1:3~1:6 | Negative | Online Inquiry |
KO00589 | IKBKG Knockout cell line(293T) | Human | IKBKG | 1:3~1:6 | Negative | Online Inquiry |
KO11068 | IKBKG Knockout cell line (HCT 116) | Human | IKBKG | 1:2~1:4 | Negative | Online Inquiry |
KO11069 | IKBKG Knockout cell line (HEK293) | Human | IKBKG | 1:3~1:6 | Negative | Online Inquiry |
KO11070 | IKBKG Knockout cell line (A549) | Human | IKBKG | 1:3~1:4 | Negative | Online Inquiry |
IKBKG Gene Knockout Cell Lines represent a cutting-edge product designed for use in molecular biology and genetic research. These specially engineered cell lines feature a stable knockout of the IKBKG gene (Inhibitor of Nuclear Factor Kappa B Kinase Gamma), which plays a crucial role in regulating the NF-κB signaling pathway. By eliminating this gene, researchers can investigate the impacts of NF-κB dysregulation on various cellular processes, including immune responses, inflammation, and apoptosis.
The key mechanism of action for these knockout cell lines lies in their ability to facilitate detailed studies of cellular signaling pathways affected by IKBKG. The absence of this gene prevents the activation of the NF-κB pathway, leading to altered cellular behavior that researchers can analyze for insights into diseases such as cancer and autoimmune disorders. These cell lines are invaluable for functional assays, pathway analysis, and drug testing, providing a unique model to decipher complex biological phenomena in vitro.
Scientific importance is underscored by the variety of applications these knockout cell lines offer in both basic and translational research settings. They are particularly relevant for studies aimed at understanding the role of NF-κB in pathologies and for the development of targeted therapies. Compared to alternative cell models, our IKBKG Gene Knockout Cell Lines provide a more refined approach by specifically removing the gene of interest, thus minimizing off-target effects and ensuring reliable results.
Researchers and clinicians will find these cell lines exceptionally valuable due to their suitability for a broad range of experimental designs, robust performance in assays, and the high-quality data they generate. This product not only supports advanced research endeavors but also enhances the potential for clinical breakthroughs.
With years of expertise in the development of high-quality biological products, our company is proud to offer IKBKG Gene Knockout Cell Lines as part of our comprehensive portfolio. We are committed to equipping researchers with the tools necessary to push the boundaries of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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