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IKBKE Knockout Cell Lines

Gene: IKBKE

Official Full Name: inhibitor of nuclear factor kappa B kinase subunit epsilonprovided by HGNC

Gene Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00238 IKBKE Knockout cell line (HEK293) Human IKBKE 1:3~1:6 Negative Online Inquiry
KO00245 IKBKE Knockout cell line (A549) Human IKBKE 1:3~1:4 Negative Online Inquiry
KO32997 IKBKE Knockout cell line (HeLa) Human IKBKE 1:3~1:6 Negative Online Inquiry
KO32998 IKBKE Knockout cell line (HCT 116) Human IKBKE 1:2~1:4 Negative Online Inquiry

Background

IKBKE Gene Knockout Cell Lines are a specialized tool designed to facilitate the examination and manipulation of the IKBKE gene, pivotal in the regulation of inflammatory responses and tumorigenesis. These cell lines have been engineered using advanced CRISPR/Cas9 technology to achieve targeted gene knockout, allowing researchers to elucidate the functional role of IKBKE in various biological processes. By disrupting the IKBKE gene, scientists can observe changes in cellular pathways and phenotypes, providing vital insights into the gene's impact on cell signaling and disease progression.

The primary mechanism of action involves the CRISPR/Cas9 system, which introduces double-strand breaks at specific genomic locations. Following the cell’s natural repair processes, this results in the disruption of the IKBKE gene, effectively silencing its expression. This gene knockout approach is instrumental for studying pathogenic mechanisms in conditions such as cancer and autoimmune diseases, where IKBKE activity is known to play a critical role.

In both research and clinical settings, IKBKE Gene Knockout Cell Lines serve as a powerful platform for drug screening and biomarker discovery. Their application extends to understanding resistance mechanisms against therapeutic agents and developing targeted therapies. The unique benefits of these cell lines include consistent and reproducible results, a well-characterized genetic background, and the potential for application across different tumor types, thus offering researchers versatile tools for in-depth analysis.

Investing in IKBKE Gene Knockout Cell Lines means gaining access to high-quality, validated models that significantly enhance the reliability of experimental outcomes. For researchers looking to delve into the complexities of gene function and its implications for health and disease, these cell lines offer an invaluable resource. Our company, with its extensive expertise in producing state-of-the-art biological products, ensures the highest standards in design and characterization of gene knockout models, empowering the scientific community with innovative solutions for advancing research.

Please note that all services are for research use only. Not intended for any clinical use.

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