Gene: IGFBP4
Official Full Name: insulin like growth factor binding protein 4provided by HGNC
Gene Summary: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37090 | IGFBP4 Knockout cell line (HeLa) | Human | IGFBP4 | 1:3~1:6 | Negative | Online Inquiry |
KO37091 | IGFBP4 Knockout cell line (HEK293) | Human | IGFBP4 | 1:3~1:6 | Negative | Online Inquiry |
KO37092 | IGFBP4 Knockout cell line (A549) | Human | IGFBP4 | 1:3~1:4 | Negative | Online Inquiry |
IGFBP4 Gene Knockout Cell Lines represent a crucial innovation in the field of molecular biology and genetics, specifically engineered to eliminate the Insulin-like Growth Factor Binding Protein 4 (IGFBP4) gene. IGFBP4 plays a significant role in the regulation of cell growth, survival, and tissue repair by modulating insulin-like growth factor (IGF) availability and activity. The knockout of this gene provides researchers with an invaluable tool to investigate the downstream effects of IGF signaling pathways and its ramifications in various physiological and pathological processes.
These cell lines function through the complete removal of the IGFBP4 gene, thus permitting a detailed study of its absence on cellular metabolism, proliferation, and differentiation. Scientists can utilize these cell lines to elucidate the role of IGFBP4 in cancer biology, diabetes, and age-related diseases. By creating a model in which researchers can observe the impacts of IGF signaling without the influence of this specific binding protein, the potential for unveiling novel therapeutic targets becomes apparent.
The scientific importance of IGFBP4 Gene Knockout Cell Lines extends into both research and clinical settings, facilitating investigations that lead to the discovery of new methods for cancer treatment, improved understanding of metabolic disorders, and potential advancements in tissue engineering. Compared to other gene knockout models, these cell lines specifically focus on IGFBP-related mechanisms and pharmacological interventions, offering a precise avenue for targeted research.
Researchers and clinicians will find value in this product due to its high specificity, reproducibility, and adaptability to various experimental conditions. The ability to manipulate signaling pathways in a controlled manner positions IGFBP4 knockout models as pivotal in predictive modeling for drug discovery and development.
Our company specializes in providing high-quality biological products with a commitment to scientific excellence. We understand the criticality of precise genetic tools in research and are dedicated to supporting the scientific community through our innovative offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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