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IER2 Knockout Cell Lines

Gene: IER2

Official Full Name: immediate early response 2provided by HGNC

Gene Summary: Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Implicated in colorectal cancer and hepatocellular carcinoma. Biomarker of childhood acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and melanoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33043 IER2 Knockout cell line (HeLa) Human IER2 1:3~1:6 Negative Online Inquiry
KO33044 IER2 Knockout cell line (HCT 116) Human IER2 1:2~1:4 Negative Online Inquiry
KO33045 IER2 Knockout cell line (HEK293) Human IER2 1:3~1:6 Negative Online Inquiry
KO33046 IER2 Knockout cell line (A549) Human IER2 1:3~1:4 Negative Online Inquiry

Background

IER2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the IER2 gene, which is implicated in various cellular functions including cell proliferation, stress response, and differentiation. These knockout cell lines are generated through advanced gene-editing technologies, such as CRISPR-Cas9, which precisely excise the IER2 gene, resulting in a robust model that allows researchers to investigate the gene's functional roles in both physiological and pathological contexts.

The primary function of IER2 gene knockout cell lines is to elucidate the biological pathways associated with IER2 expression. By systematically comparing these knockout lines to wild-type cell lines, scientists can discern the gene's contributions to cellular processes, including apoptosis, signal transduction, and metabolic regulation. Additionally, these models can aid in studying the gene's involvement in diseases, such as cancer and neurodegenerative disorders, where deregulation of IER2 may play a critical role.

The scientific importance of IER2 gene knockout cell lines lies in their capacity to address fundamental questions in gene function and molecular mechanisms. They serve as invaluable tools for drug discovery, biomarker identification, and the development of therapeutic strategies. This product finds critical applications in both academic research and clinical settings, facilitating advancements in personalized medicine and targeted therapies.

One of the distinct advantages of our IER2 gene knockout cell lines is their high specificity and reliability, offering consistent results that are often superior to conventional methods that rely on transient transfection or siRNA knockdown, which may have off-target effects. Moreover, our cell lines are rigorously validated for their functionality and phenotype, saving researchers time and resources on unnecessary preliminary experiments.

For researchers and clinicians focused on gene function and its implications in disease, our IER2 gene knockout cell lines provide a robust framework for innovative exploration. These cell lines enable precise manipulation of cellular environments, making them an essential asset for teams striving to advance scientific discovery and therapeutic development.

Our company brings extensive expertise in the design and production of high-fidelity biological products, leveraging state-of-the-art technologies to ensure each product meets the rigorous standards required by today’s research landscape. With a commitment to quality and innovation, we empower scientists to transform their research into impactful solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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