Home / HTRA2 Knockout Cell Lines

HTRA2 Knockout Cell Lines

Gene: HTRA2

Official Full Name: HtrA serine peptidase 2provided by HGNC

Gene Summary: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00435 HTRA2 Knockout cell line (HEK293) Human HTRA2 1:3~1:6 Negative Online Inquiry

Background

HTRA2 Gene Knockout Cell Lines are genetically engineered cellular models that have had the HTRA2 gene disrupted or completely knocked out. This gene encodes a serine protease that plays a critical role in regulating apoptotic pathways and mitochondrial function. By employing sophisticated gene editing technologies such as CRISPR/Cas9, these cell lines allow researchers to investigate the biological consequences of HTRA2 loss, providing insights into its involvement in various cellular processes including apoptosis, neurodegeneration, and cancer.

The mechanism underlying the utility of HTRA2 Gene Knockout Cell Lines lies in their ability to mimic pathological conditions associated with HTRA2 dysfunction. Researchers can utilize these models to explore altered signaling pathways, assess drug efficacy, and examine compensatory mechanisms that may arise due to gene inactivation. Importantly, the HTRA2 gene has been implicated in several diseases, making these cell lines valuable tools for studying conditions like Parkinson's disease and various cancer types, as well as for the development of targeted therapies.

Compared to traditional methods of studying gene function, HTRA2 Gene Knockout Cell Lines offer distinct advantages. They provide a reproducible and controlled environment that minimizes inter-sample variability while enabling high-throughput screening opportunities. Unlike other genetic models, these knockout lines facilitate a direct assessment of the gene's impact on cellular function without confounding factors from normal gene expression.

For researchers and clinicians, the value of HTRA2 Gene Knockout Cell Lines cannot be overstated. They represent a crucial resource for dissecting the complex roles of HTRA2 in cell biology and disease mechanisms, thereby driving innovations in therapeutic development. Our company specializes in creating high-quality genetic models for life science research, and our expertise ensures that you receive robust, well-characterized HTRA2 Gene Knockout Cell Lines that meet the rigorous demands of modern scientific inquiry. With an unwavering commitment to quality and innovation, we empower researchers with the tools necessary to advance their studies and translate findings into clinical solutions.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.