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HPS3 Knockout Cell Lines

Gene: HPS3

Official Full Name: HPS3 biogenesis of lysosomal organelles complex 2 subunit 1provided by HGNC

Gene Summary: This gene encodes a protein containing a potential clathrin-binding motif, consensus dileucine signals, and tyrosine-based sorting signals for targeting to vesicles of lysosomal lineage. The encoded protein may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 3. [provided by RefSeq, Apr 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24900 HPS3 Knockout cell line (HeLa) Human HPS3 1:3~1:6 Negative Online Inquiry
KO24901 HPS3 Knockout cell line (HCT 116) Human HPS3 1:2~1:4 Negative Online Inquiry
KO24902 HPS3 Knockout cell line (HEK293) Human HPS3 1:3~1:6 Negative Online Inquiry
KO24903 HPS3 Knockout cell line (A549) Human HPS3 1:3~1:4 Negative Online Inquiry

Background

HPS3 Gene Knockout Cell Lines are advanced, genetically modified cellular models specifically designed to investigate the function of the HPS3 gene, which is implicated in Hermansky-Pudlak Syndrome as well as other cellular processes related to lysosomal trafficking and pigmentation. Through the targeted deletion of the HPS3 gene, these knockout lines allow researchers to elucidate gene function, disease mechanisms, and potential therapeutic pathways.

The primary mechanism of action involves the CRISPR-Cas9 gene-editing technology, which enables precise modifications to the cellular DNA. This results in a stable knockout of the HPS3 gene, facilitating the study of its role in cellular functions such as autophagy, melanin synthesis, and granular organelle dynamics. These cell lines serve as a powerful tool in the functional genomics arena, allowing researchers to delve into the gene's involvement in various biological processes and understand its contribution to disease pathology.

Scientifically, the HPS3 Gene Knockout Cell Lines are vital for research in genetics, cell biology, and pharmacology, as they can be utilized to screen for potential drugs, study gene interactions, and model associated diseases. Their application spans basic research to translational studies, making them indispensable for laboratories focused on genetic disorders.

What sets our HPS3 Gene Knockout Cell Lines apart from alternative models is the rigor of our gene-editing process, ensuring high specificity and efficiency with minimal off-target effects. Furthermore, these cell lines come with extensive characterizations, including confirmation of knockout efficiency and functional analysis data, which enhances their reliability for scientific research.

For researchers, clinicians, and pharmaceutical companies, the ability to manipulate and study cell lines with known genetic alterations holds immense value, supporting mechanistic studies that can lead to ground-breaking therapeutic developments. Investing in HPS3 Gene Knockout Cell Lines aligns with your commitment to advance scientific understanding and innovative discoveries.

Our company excels in providing cutting-edge biological products, ensuring that our offerings are backed by robust scientific data and exceptional quality control. With a focus on innovation and customer support, we empower researchers and clinicians with the tools necessary to advance their work.

Please note that all services are for research use only. Not intended for any clinical use.

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