Gene: HOXC6
Official Full Name: homeobox C6provided by HGNC
Gene Summary: This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37256 | HOXC6 Knockout cell line (HeLa) | Human | HOXC6 | 1:3~1:6 | Negative | Online Inquiry |
KO37257 | HOXC6 Knockout cell line (HCT 116) | Human | HOXC6 | 1:2~1:4 | Negative | Online Inquiry |
KO37258 | HOXC6 Knockout cell line (HEK293) | Human | HOXC6 | 1:3~1:6 | Negative | Online Inquiry |
KO37259 | HOXC6 Knockout cell line (A549) | Human | HOXC6 | 1:3~1:4 | Negative | Online Inquiry |
HOXC6 Gene Knockout Cell Lines are engineered cellular models designed specifically to study the biological roles and regulatory mechanisms of the HOXC6 gene, a crucial member of the homeobox gene family involved in various developmental processes. These knockout cell lines have been meticulously created via CRISPR/Cas9 technology, ensuring that the HOXC6 gene is effectively disrupted, resulting in a complete loss of function. This genetic manipulation allows researchers to gain unprecedented insights into the gene's contribution to cellular fate decisions, differentiation, and the potential oncogenic pathways influenced by HOXC6.
The primary function of HOXC6 Gene Knockout Cell Lines lies in their ability to elucidate the gene’s role in various biological contexts, such as embryonic development, organogenesis, and disease pathology. By observing the phenotypic and molecular changes that occur upon HOXC6 disruption, researchers can better understand the gene's signaling mechanisms, interactions with other regulatory factors, and its involvement in developmental disorders or malignancies.
The scientific importance of these knockout cell lines is underscored by their wide-ranging applications in both basic research and clinical settings. They provide a vital tool for exploring the underlying mechanisms of HOXC6 in cancer biology, where its aberrant expression is often correlated with tumorigenesis. These models enable targeted drug discovery efforts and the development of innovative therapeutic strategies to counteract HOXC6-associated pathologies.
Compared to traditional methods of gene silencing, such as RNA interference, HOXC6 Gene Knockout Cell Lines offer several advantages. The CRISPR/Cas9 method provides a permanent gene modification, which allows for consistent and reproducible results across experiments. Moreover, these cell lines can be customized for specific assays, making them versatile for various experimental conditions.
For researchers and clinicians invested in genetic studies, developmental biology, or cancer research, the value of HOXC6 Gene Knockout Cell Lines cannot be overstated. They serve as a fundamental resource for unraveling complex biological questions and contribute toward advancements in personalized medicine and targeted therapies.
Our company specializes in innovative genetic modeling and is committed to providing cutting-edge tools that empower the scientific community. By leveraging our expertise, researchers can advance their studies with confidence, knowing they are equipped with the highest quality biological products available.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.