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HOXB8 Knockout Cell Lines

Gene: HOXB8

Official Full Name: homeobox B8provided by HGNC

Gene Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37253 HOXB8 Knockout cell line (HCT 116) Human HOXB8 1:2~1:4 Negative Online Inquiry
KO37254 HOXB8 Knockout cell line (HEK293) Human HOXB8 1:3~1:6 Negative Online Inquiry
KO37255 HOXB8 Knockout cell line (A549) Human HOXB8 1:3~1:4 Negative Online Inquiry

Background

HOXB8 Gene Knockout Cell Lines are specialized cellular models engineered to have a targeted deletion of the HOXB8 gene, a member of the homeobox gene family that plays a crucial role in various developmental and cellular processes, including hematopoiesis and limb formation. By utilizing CRISPR-Cas9 technology for precise gene editing, these knockout cell lines enable researchers to investigate the functional implications of HOXB8 loss in a controlled environment, providing invaluable insights into gene regulation, differentiation pathways, and disease mechanisms.

The primary function of HOXB8 Gene Knockout Cell Lines is to facilitate the study of gene expression and its resultant biological impacts. With the HOXB8 gene inactivated, researchers can explore changes in cellular phenotypes, signaling pathways, and gene networks that are otherwise masked in wild-type cells. This model is particularly important for research in fields such as developmental biology and oncology, where understanding the role of specific genes can lead to the discovery of novel therapeutic targets and biomarkers.

The significance of these cell lines extends into clinical research and pharmacological applications. By offering a precise model for studying gene function, they help elucidate the molecular underpinnings of diseases such as hematologic disorders and specific cancers associated with HOXB8 dysregulation. This makes the HOXB8 Gene Knockout Cell Lines an indispensable tool for investigators aiming to develop targeted interventions.

Compared to conventional cell lines that express HOXB8, our knockout models provide a unique competitive advantage by allowing for direct observation of gene function without confounding effects, ultimately streamlining experiments and enhancing data reliability. Additionally, our cell lines come with a guarantee of quality and reproducibility, having undergone rigorous validation.

In the realm of biological research, having access to highly specific and well-characterized models can significantly accelerate the pace of discovery, making the HOXB8 Gene Knockout Cell Lines a valuable asset to any lab focused on cutting-edge research. Our company, with its extensive background in genetic engineering and commitment to scientific excellence, is dedicated to delivering innovative products that empower researchers to advance their understanding of genetic influences on cellular behavior.

Please note that all services are for research use only. Not intended for any clinical use.

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