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HOXB5 Knockout Cell Lines

Gene: HOXB5

Official Full Name: homeobox B5provided by HGNC

Gene Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37272 HOXB5 Knockout cell line (HeLa) Human HOXB5 1:3~1:6 Negative Online Inquiry
KO37273 HOXB5 Knockout cell line (HCT 116) Human HOXB5 1:2~1:4 Negative Online Inquiry
KO37274 HOXB5 Knockout cell line (HEK293) Human HOXB5 1:3~1:6 Negative Online Inquiry
KO37275 HOXB5 Knockout cell line (A549) Human HOXB5 1:3~1:4 Negative Online Inquiry

Background

HOXB5 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to possess a disruption in the HOXB5 gene, a member of the homeobox gene family that plays a pivotal role in developmental processes and cellular differentiation. By employing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines enable the study of HOXB5's function and regulation, providing an essential tool for investigating its contribution to various biological pathways, particularly in the context of tumorigenesis and embryonic development.

The cell lines function by offering a controlled environment in which the effects of HOXB5 gene loss can be observed. Researchers can analyze changes in cell behavior—such as proliferation, migration, and apoptosis—thus elucidating the biological significance of HOXB5 in different cellular contexts. This information is particularly critical in cancer research, where aberrant expression of homeobox genes has been implicated in cancer progression and metastasis.

In terms of scientific importance, HOXB5 Gene Knockout Cell Lines serve as invaluable models for understanding gene function and regulatory networks in both fundamental and translational research settings. Their application extends to drug discovery, where researchers aim to identify potential therapeutic targets and biomarkers for precision medicine.

The specific advantages of our HOXB5 Gene Knockout Cell Lines lie in their high efficiency of knockout and the proven reliability of the gene-editing methodology applied. Unlike conventional methods that may yield inconsistent results or require extensive validation, our products provide a robust platform for experimental design, significantly reducing the time and resources needed for research.

Investing in HOXB5 Gene Knockout Cell Lines empowers researchers and clinicians by offering a reliable and efficient way to dissect the role of HOXB5 in various biological processes and diseases. Our rigorous quality control processes ensure that each cell line provided meets the highest standards, enabling reproducible, high-impact results in any research scenario.

As a leading provider of innovative biological products, our expertise in genetic engineering and commitment to research excellence position us as an exceptional partner for advancing scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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