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HOXB2 Knockout Cell Lines

Gene: HOXB2

Official Full Name: homeobox B2provided by HGNC

Gene Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02205 HOXB2 Knockout cell line (HeLa) Human HOXB2 1:3~1:6 Negative Online Inquiry
KO02206 HOXB2 Knockout cell line (HCT 116) Human HOXB2 1:2~1:4 Negative Online Inquiry
KO02207 HOXB2 Knockout cell line (HEK293) Human HOXB2 1:3~1:6 Negative Online Inquiry
KO02208 HOXB2 Knockout cell line (A549) Human HOXB2 1:3~1:4 Negative Online Inquiry

Background

HOXB2 Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically designed to eliminate the HOXB2 gene's expression, allowing researchers to study the gene's role in various biological processes and diseases. This innovative product facilitates the exploration of HOXB2's contributions to developmental biology, cancer research, and regenerative medicine by providing an in vivo-like environment where the effects of gene loss can be thoroughly analyzed.

The primary function of these knockout cell lines lies in their ability to enable researchers to dissect the intricate pathways that HOXB2 influences. By utilizing CRISPR-Cas9 technology for precise gene editing, the knockout cell lines effectively silence HOXB2 expression. This mechanism not only aids in revealing the gene's function but also highlights downstream signaling pathways that may be affected by its absence, thus shedding light on its role in cell differentiation, proliferation, and apoptosis.

Scientifically, HOXB2 Gene Knockout Cell Lines hold significant importance across both research and clinical applications. In cancer research, understanding the oncogenic potential of HOXB2 can lead to novel therapeutic targets, while in developmental biology, these models can elucidate critical mechanisms underlying embryogenesis and tissue patterning. Furthermore, they provide an essential tool for drug discovery, allowing for high-throughput screening of novel compounds in HOXB2-related pathways.

Compared to traditional knockdown approaches that rely on RNA interference, our HOXB2 knockout cell lines provide more stable and precise loss-of-function analysis, ensuring reproducibility and accuracy in experimental results. Their versatility for use in various cell types, and compatibility with standard culture conditions make them a valuable addition to any molecular biology or genetic research laboratory.

For researchers, clinicians, and pharmaceutical developers, the HOXB2 Gene Knockout Cell Lines offer unparalleled insights into the gene's role and are critical for advancing our understanding of related diseases. Backed by a team of experts with extensive experience in genetic engineering and cellular biology, our product line not only underscores commitment to quality and innovation but also aims to empower advancements in biomedicine.

Please note that all services are for research use only. Not intended for any clinical use.

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