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HOXA6 Knockout Cell Lines

Gene: HOXA6

Official Full Name: homeobox A6provided by HGNC

Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03473 HOXA6 Knockout cell line (HCT 116) Human HOXA6 1:2~1:4 Negative Online Inquiry
KO03474 HOXA6 Knockout cell line (HEK293) Human HOXA6 1:3~1:6 Negative Online Inquiry
KO03475 HOXA6 Knockout cell line (A549) Human HOXA6 1:3~1:4 Negative Online Inquiry

Background

HOXA6 Gene Knockout Cell Lines are specialized cellular models engineered to have inactivated HOXA6 gene expression, a critical factor in developmental biology and oncogenesis. These knockout cell lines facilitate the functional study of HOXA6, providing researchers with invaluable insights into the gene's role in cellular processes such as differentiation, proliferation, and migration. By employing CRISPR-Cas9 technology, the resultant cell lines exhibit stable mutations that enable the examination of HOXA6's influence without the interference of wild-type alleles.

The functional mechanisms through which HOXA6 operates are multifaceted, including participation in the regulation of developmental pathways and gene expression networks. Disruption of HOXA6 can unveil its contribution to various pathological states, including cancers where its dysregulation has been implicated. By utilizing these knockout cell lines, researchers can explore the gene's downstream effects, mutations, and potential interactions with other genes in both in vitro and in vivo settings.

The scientific importance of the HOXA6 Gene Knockout Cell Lines is underscored by their utility in laboratory research, particularly in cancer studies and developmental biology. They are instrumental in identifying novel therapeutic targets and understanding the molecular underpinnings of diseases where HOXA6 is aberrantly expressed. Unlike conventional methods of gene silencing, the permanent knockout provided by these cell lines allows for long-term studies and avoids issues related to transient expression or incomplete knockdown.

Researchers, clinicians, and biotechnologists will find these knockout cell lines particularly advantageous due to their reliability, predictability, and ease of use in a variety of experimental paradigms. They offer a robust platform for high-throughput screening and drug discovery applications, thereby streamlining research workflows while enhancing the reproducibility of results.

Our company is committed to advancing biological research through high-quality genetic tools, and with our expertise in gene editing technologies, we ensure that our HOXA6 Gene Knockout Cell Lines meet the rigorous standards demanded by the scientific community. By choosing our product, customers are investing in dependable and innovative solutions tailored to their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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