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HOXA11 Knockout Cell Lines

Gene: HOXA11

Official Full Name: homeobox A11provided by HGNC

Gene Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04437 HOXA11 Knockout cell line (HeLa) Human HOXA11 1:3~1:6 Negative Online Inquiry
KO04438 HOXA11 Knockout cell line (HCT 116) Human HOXA11 1:2~1:4 Negative Online Inquiry
KO04439 HOXA11 Knockout cell line (HEK293) Human HOXA11 1:3~1:6 Negative Online Inquiry
KO04440 HOXA11 Knockout cell line (A549) Human HOXA11 1:3~1:4 Negative Online Inquiry

Background

HOXA11 Gene Knockout Cell Lines are specialized cell lines engineered to have a complete loss-of-function for the HOXA11 gene, a critical transcription factor that plays a significant role in embryonic development and cellular differentiation. Through the use of CRISPR-Cas9 gene-editing technology, these cell lines enable researchers to investigate the functional consequences of HOXA11 deficiency, elucidating its involvement in various biological processes, including limb development and reproductive system formation.

The key function of HOXA11 Gene Knockout Cell Lines lies in their ability to model the pathophysiological effects associated with disrupted HOXA11 expression. By examining cellular behavior, gene expression profiles, and signaling pathways in these knockout models, researchers can gain insight into the molecular mechanisms underpinning developmental disorders and certain cancers. This product is essential in both basic and translational research settings, where understanding the nuanced role of HOXA11 can lead to the identification of novel therapeutic targets.

Compared to alternative cell models, such as wild-type lines or those subjected to chemical inhibitors, HOXA11 Gene Knockout Cell Lines provide a more specific and robust approach for studying the direct effects of gene loss without the confounding influences of off-target effects or compensatory mechanisms. Furthermore, these knockout lines can be utilized in high-throughput screening applications, paving the way for drug discovery and the development of innovative therapeutic strategies.

For researchers and clinicians, the value of HOXA11 Gene Knockout Cell Lines lies not just in the elucidation of complex biological pathways but also in their potential to contribute to improved patient outcomes through the advancement of personalized medicine. By tapping into the fundamental biology defined by HOXA11, this product represents a powerful tool in the arsenal of modern biomedical research.

Our company, with its extensive expertise in genetic engineering and commitment to quality biological products, offers HOXA11 Gene Knockout Cell Lines to meet the evolving needs of the scientific community, ensuring that researchers have access to vital tools for groundbreaking discoveries in developmental biology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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